Access to 3-alkylselenindoles by multicomponent reaction of indoles,selenium powder and unactivated alkyl halides under transition-metal-free conditions  

作　　者：Huan Liu Zhong-Jian Cai Shun-Jun Ji 

机构地区：[1]Key Laboratory of Organic Synthesis of Jiangsu Province,College of Chemistry,Chemical Engineering and Materials Science&Collaborative Innovation Center of Suzhou Nano Science and Technology,Soochow University,Suzhou 215123,China

出　　处：《Chinese Chemical Letters》2022年第9期4303-4305,共3页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(No.21672157);PAPD,the project of scientific and technologic infrastructure of Suzhou(No.SZS201708);Natural Science Foundation of Jiangsu Province(No.BK20200874);Natural Science Foundation for colleges and universities in Jiangsu Province(No.20KJD150001)。

摘　　要：Herein,we reported a convenient and efficient multicomponent reaction of indoles,selenium powder and unactivated alkyl halides.This protocol provides a practical,and facile approach for the synthesis of 3-alkylselenindole derivatives.The advantages of this strategy include mild and transition-metal-free conditions,broad functional group tolerance,the use of simple and easily accessible seleniium powder and alkyl halides as coupling partners.More importantly,the reaction proceeded smoothly with a large scale(>10 g,>90%yield),which further highlighted the potential application of this selenation strategy.

关 键 词：SELENIUM 3-Alkylselenindole INDOLE SELENIZATION 

分 类 号：O626[理学—有机化学]