Effect of Antibacterial Enoxacin on the Properties of Injectable Nano-hydroxyapatite/Polyurethane Cement for Bone Repairing  

作　　者：Jinzheng Zhang Xiaoyu Lei Jiajing Tang Jie Chen Qing Zhao Wei Fang Yinglong Zhang Yubao Li Yi Zuo 

机构地区：[1]Research Center for Nano-Biomaterials,Analytical and Testing Center,Sichuan University,Chengdu 610064,People’s Republic of China

出　　处：《Journal of Bionic Engineering》2022年第2期483-496,共14页仿生工程学报（英文版）

基　　金：funded by the Sichuan International Science and Technology Innovation Cooperation Project[Grant Numbers2021YFH0122];the Fundamental Research Funds for the Central Universities。

摘　　要：Biomaterial-associated infection(BAI)is a kind of serious post-operative complication in orthopaedic surgery.Antibiotic-loaded bone cement shines a light on BAI prevention for convenient manipulation and complex filling.To this aim,we designed an antibacterial bone cement based on Nano-hydroxyapatite/Polyurethane(PUHA)loading with antibiotic Enoxacin(EN).The distinct shear-thinning behavior of the prepolymers was observed,indicating a good injectability.The PUHA bone cement possessed a suitable curing speed,and the addition of EN might slightly expedite the curing process and enhance the mechanical properties.The EN release profile indicated that the EN-loaded bone cement could reach the minimum inhibitory concentration in 2 h,and sustainedly released EN for almost 8 days,exhibiting an antibacterial delivery potential.Antibacterial test further confirmed the antibacterial ability of EN-loaded bone cement is in a dose-dependent manner.However,the osteogenic performance of drug-loaded bone cement with high dosage is not as good as antibacterial activity.When the EN concentration of antibacterial cement was lower than 32μg·mL^(-1),the proliferation and osteogenic differentiation of rat mesenchymal stem cells could be significantly promoted.Overall,this study verified the potential of the EN-loaded PUHA bone cement in anti-infection and osteogenesis for bone repairing.

关 键 词：Antibacterial bone cement Nano-hydroxyapatite/polyurethane Enoxacin Shear-thinning behavior OSTEOGENESIS 

分 类 号：TB383[一般工业技术—材料科学与工程]