Thiocytochalasins A−D,four sulfur-containing cytochalasans from an endophytic fungus Phoma multirostrata XJ-2-1  

作　　者：Xiaogang Peng Jinling Chang Ying Gao Fangfang Duan Hanli Ruan 

机构地区：[1]School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation,Wuhan 430030,China

出　　处：《Chinese Chemical Letters》2022年第10期4572-4576,共5页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(Nos.22077041 and 31770380).

摘　　要：Four unprecedented sulfur-containing cytochalasans,thiocytochalasins A−D(1−4),were isolated from an endophytic fungus Phoma multirostrata XJ-2-1.Thiocytochalasins A(1)and B(2)feature a novel 5/6/14/5 tetracyclic scaffold,which are the first examples of cytochalasan containing a thiophene moiety.Thiocytochalasins C(3)and D(4)are epimeric cytochalasan homodimers formed via a thioether bridge.Their structures with absolute configurations were established by detailed analysis of the HRESIMS,NMR,and X-ray crystallography.The plausible biogenetic pathway of 1−4 was postulated.Compounds 3 and 4 exhibited significant cytotoxicity against CT26 cells with IC_(50) values of 0.85 and 0.76µmol/L,respectively.

关 键 词：Phoma multirostrata XJ-2-1 Sulfur-containing cytochalasans Thiocytochalasins A-D CYTOTOXICITY Cell cycle 

分 类 号：Q936[生物学—微生物学]