A glutathione activatable pro-drug-photosensitizer for combined chemotherapy and photodynamic therapy  

作　　者：Yanjun Yang Yifeng Zhang Ran Wang Xiang Rong Ting Liu Xiang Xia Jiangli Fan Wen Sun Xiaojun Peng 

机构地区：[1]State Key Laboratory of Fine Chemicals,Dalian University of Technology,Dalian 116024,China [2]Ningbo Institute of Dalian University of Technology,Ningbo 315016,China

出　　处：《Chinese Chemical Letters》2022年第10期4583-4586,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.22090011,22078046,21808028);NSFC Liaoning United Fund(No.U1908202)。

摘　　要：During cancer treatment,chemotherapeutic drugs always result in severe side-effects and drug resistance.Therefore,combining cheomtherapy with other therapeutic modalities,such as photodynamic therapy(PDT)and designing an activable platform is promising for precise and efficient anticancer treatment.Herein,we report a“pro-drug-photosensitizer”agent,LMB-S-CPT,bearing a disulfide bond as the glutathione(GSH)-activatable linker.LMB-S-CPT can be selectively activated by GSH to release activated drug,camptothecin(CPT),for chemotherapy and activated photosensitizer,methylene blue(MB),for PDT.LMB-S-CPT exhibits excellent tumor-activatable performance when injected into tumor-bearing mice,as well as specific cancer therapy with negligible toxic side effects.The activatable pro-drug-photosensitizer offers a new strategy for chemo-photodynamic therapy and displays precise,selective and excellent antitumor effect.

关 键 词：Pro-drug-photosensitizer CHEMOTHERAPY Photodynamic therapy GSH activation 

分 类 号：TQ460.1[化学工程—制药化工] R730.53[医药卫生—肿瘤]