低危妊娠滋养细胞肿瘤的治疗  

Treatment for low-risk gestational trophoblastic neoplasia.

作　　者：刘晓梅 李秀琴[1] LIU Xiao-mei;LI Xiuqin(Department of Obstetricsand Gynecology hengjing Hospital of China MedicalUniversity,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院妇产科,辽宁沈阳110004

出　　处：《中国实用妇科与产科杂志》2022年第7期687-691,共5页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：针对低危妊娠滋养细胞肿瘤(gestational trophoblastic neoplasia,GTN)的治疗,在国际妇产科联盟(FIGO)指南推荐的化疗基础上,应该再次分层,0~4分选择放线菌素-D(Act-D)或甲氨蝶呤(MTX)单药化疗,根据一些研究报道,Act-D的疗效优于MTX,而且副反应发生率更低;5~6分者目前建议单药化疗,但可放宽联合化疗方案的适应证。化疗期间密切监测疗效,如果单药化疗耐药,可以个体化的更换另一种单药或联合方案。The treatment of low-risk gestational trophoblastic neoplasia,based on the chemotherapy recommended by FIGO guidelines,should be stratified again,and actinomycin D(Act-D)or methotrexate(MTX)single-agent chemotherapy should be selected for those of 0-4 points.According to some research reports,the efficacy of Act-D is better than that of MTX,and the side effects are lower;single-agent chemotherapy is recommended for those with a score of 5-6,but the indications for combined chemotherapy can be broadened.The curative effect should be closely monitored during chemotherapy,and if the single-agent chemotherapy is resistant,another single-agent or combination regimen can be used individually.

关 键 词：妊娠滋养细胞肿瘤 低危 分层治疗 

分 类 号：R737.33[医药卫生—肿瘤]