Structural landscape investigations on bendable plastic crystals of isonicotinamide polymorphs  

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作  者:Jianting Li Jiaquan Li Hongji Liu Li Zhang Yang Lu Zhengzheng Zhou 

机构地区:[1]NMPA Key Laboratory for Safety Evaluation of Cosmetics,Guangdong Provincial Key Laboratory of Tropical Disease Research,Department of Hygiene Inspection&Quarantine Science,School of Public Health,Southern Medical University,Guangzhou 510515,China [2]Beijing City Key Laboratory of Polymorphic Drugs,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China

出  处:《Chinese Chemical Letters》2022年第8期4069-4073,共5页中国化学快报(英文版)

基  金:sponsored by National Key R&D Program of China(No.2016YFC1000900);National Science and Technology Major Project of China(No.2018ZX09711001-001-013);National Natural Science Foundation of China(No.81703438)。

摘  要:Three polymorphs(forms I,II and V)of isonicotinamide(INA)were mechanically flexible and exhibited one-dimensional(1 D)plasticity.Anisotropic intermolecular interactions contribute to the plasticity of single crystals:weak dispersive interactions between slip planes such as 1 D columns in forms I and II or 2 D layers in form V were stabilized by strong hydrogen bonds,allowing the layer or column's surface to glide smoothly without hindrance.The disparity of intermolecular interactions on plastic properties of INA polymorphic crystals was confirmed by energy framework analysis,nanoindentation tests and micro-Raman spectroscopy.The crystal which exhibits plastic property provides a promising application in pharmaceuticals and material sciences.

关 键 词:ISONICOTINAMIDE POLYMORPH PLASTICITY Slip plane Bending crystal 

分 类 号:TQ320.7[化学工程—合成树脂塑料工业]

 

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