Selective Ni-catalyzed cross-electrophile coupling of alkynes,fluoroalkyl halides,and vinyl halides  

作　　者：Yubei Dai Fang Wang Shengqing Zhu Lingling Chu 

机构地区：[1]State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,Center for Advanced Low-Dimension Materials,College of Chemistry,Chemical Engineering and Biotechnology,Donghua University,Shanghai 201620,China

出　　处：《Chinese Chemical Letters》2022年第8期4074-4078,共5页中国化学快报（英文版）

基　　金：financial support provided by the National Natural Science Foundation of China(Nos.21991123,21971036,21901036);the Shanghai Rising-Star Program(No.20QA1400200)。

摘　　要：We report a Ni-catalyzed three-component cross-electrophile coupling of alkynes with alkenyl halides and fluoroalkyl halides to generate fluoroalkyl-incorporated 1,3-dienes.This mild and operationally simple protocol is distinguished by its broad substrate scope and excellent chemo-,regio-,and stereo-selectivity,offering a new and organometallic agent-free platform for the construction of fluoroalkyl-incorporated diene motifs.Preliminary mechanistic studies have been conducted to probe the potential reaction pathway.

关 键 词：FLUOROALKYLATION Cross-electrophile coupling Nickel catalysis Difunctionalization ALKYNES 

分 类 号：O621.251[理学—有机化学]