伊布利特联合胺碘酮治疗食管癌术后并发急性房颤的疗效观察  

Effect of ibutilide combined with amiodarone in the treatment of acute atrial fibrillation after esophageal cancer surgery

作　　者：刘影 李小莉[2] 程洁[2] LIU Ying;LI Xiaoli;CHENG Jie(Department of Emergency,Xinyang Central Hospital,Xinyang 464000,He’nan,China;Department of Emergency,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450042,He’nan,China)

机构地区：[1]信阳市中心医院急诊科,河南信阳464000 [2]郑州大学第一附属医院急诊科,郑州450042

出　　处：《癌症进展》2022年第14期1441-1444,共4页Oncology Progress

摘　　要：目的 观察并探讨伊布利特联合胺碘酮治疗食管癌术后并发急性房颤的疗效。方法 将102例食管癌术后并发急性房颤患者按治疗方式不同分为对照组50例和观察组52例。对照组患者予以伊布利特治疗,观察组患者予以伊布利特联合胺碘酮治疗。比较两组患者用药后有效率、转复情况、不良反应发生情况以及用药前后血压及心率。结果 观察组患者用药后有效率高于对照组,差异有统计学意义(P﹤0.05)。用药后30、60、90、120、480 min,观察组患者转复例数所占比例均高于对照组,差异均有统计学意义(P﹤0.05)。用药后,两组患者收缩压、舒张压、心率均低于本组用药前,差异均有统计学意义(P﹤0.05)。两组患者用药后不良反应总发生率比较,差异无统计学意义(P﹥0.05)。结论 伊布利特联合胺碘酮治疗食管癌术后并发急性房颤的疗效佳,有利于患者心律早期转复,同时安全性良好。Objective To observe and explore the efficacy of ibutilide combined with amiodarone in the treatment of acute atrial fibrillation after esophageal cancer surgery. Method A total of 102 patients with acute atrial fibrillation after esophageal cancer surgery were divided into control group(n=50) and observation group(n=52) according to different treatment methods. The patients in the control group were treated with ibutilide, and the patients in the observation group were treated with ibutilide combined with amiodarone. The effective rate, conversion, adverse events, blood pressure and heart rate before and after the treatment were compared between the two groups. Result The effective rate of the observation group was higher than that of the control group, and the difference was statistically significant(P<0.05). At 30, 60,90, 120, and 480 minutes after the treatment, the proportion of patients in the observation group who achieved successful conversion were higher than those, and the differences were statistically significant(P<0.05). After the treatment, the systolic blood pressure, diastolic blood pressure, and heart rate of the two groups were lower than those before treatment, and the differences were statistically significant(P<0.05). There was no significant difference in the total incidence of adverse events between the two groups after the treatment(P>0.05). Conclusion The employment of ibutilide combined with amiodarone in the treatment of acute atrial fibrillation after esophageal cancer surgery could achieve a good effect, which is beneficial to the early cardioversion of patients with good safety.

关 键 词：食管癌 急性房颤 伊布利特 胺碘酮 疗效 

分 类 号：R735.1[医药卫生—肿瘤]