癌胚抗原、鳞状细胞癌抗原、细胞角质蛋白19片段抗原21-1联合检测对肺癌的诊断价值  

Diagnostic value of combined detection of carcinoembryonic antigen,squamous cell carcinoma antigen,and cyto-keratin 19 fragment antigen 21-1 in lung cancer

作　　者：高鹏宇 杨桦 刘学文[1] GAO Pengyu;YANG Hua;LIU Xuewen(Clinical Laboratory,General Hospital of Zhengzhou Coal Industry(Group)Co.,LTD.,Zhengzhou 452371,He’nan,China)

机构地区：[1]郑州煤炭工业(集团)有限责任公司总医院检验科,郑州452371

出　　处：《癌症进展》2022年第14期1497-1500,1504,共5页Oncology Progress

摘　　要：目的探讨癌胚抗原(CEA)、鳞状细胞癌抗原(SCC-Ag)、细胞角质蛋白19片段抗原21-1(CYFRA21-1)联合检测对肺癌的诊断价值。方法选取102例肺癌患者、100例肺部良性疾病患者及80例健康体检者,分别作为恶性组、良性组及对照组。比较3组研究对象的血清CEA、SCC-Ag、CYFRA21-1水平,比较不同病理类型肺癌患者的血清CEA、SCC-Ag、CYFRA21-1水平,分析CEA、SCC-Ag、CYFRA21-1单独及联合检测对肺癌的诊断价值。结果恶性组患者的血清CEA、SCC-Ag、CYFRA21-1水平均高于良性组和对照组,差异均有统计学意义(P﹤0.05)。102例肺癌患者中,34例腺癌,50例鳞状细胞癌,18例小细胞癌。腺癌患者的血清CEA水平高于鳞状细胞癌和小细胞癌患者,血清SCC-Ag水平低于鳞状细胞癌患者,血清SCC-Ag、CYFRA21-1水平均高于小细胞癌患者,差异均有统计学意义(P﹤0.05);鳞状细胞癌患者的血清CEA、SCC-Ag、CYFRA21-1水平均高于小细胞癌患者,差异均有统计学意义(P﹤0.05)。CEA、SCC-Ag、CYFRA21-1联合检测诊断肺癌的灵敏度、特异度、阳性预测值、阴性预测值分别为98.04%、95.00%、95.24%、97.94%,均高于3项指标单独检测。结论肺癌患者的血清CEA、SCC-Ag、CYFRA21-1水平均较高,联合检测对肺癌具有较好的诊断价值。Objective To investigate the diagnostic value of combined detection of carcinoembryonic antigen(CEA),squamous cell carcinoma antigen(SCC-Ag),and cyto-keratin 19 fragment antigen 21-1(CYFRA21-1)in lung cancer.Method A total of 102 patients with lung cancer,100 patients with benign lung diseases,and 80 healthy subjects were selected as malignant group,benign group,and control group,respectively.The serum CEA,SCC-Ag,and CYFRA21-1 levels of the three groups were compared.The serum levels of CEA,SCC-Ag,and CYFRA21-1 in patients with different pathological types of lung cancer were compared.The value of CEA,SCC-Ag,and CYFRA21-1 alone and in combination detection in the diagnosis of lung cancer were also analyzed.Result The serum levels of CEA,SCC-Ag,and CYFRA21-1 in the malignant group were higher than those in the benign group and the control group,and the differences were statistically significant(P<0.05).Among the 102 lung cancer patients,34 were adenocarcinoma,50 were squamous cell carcinoma,and 18 were small cell carcinoma.The level of serum CEA in patients with adenocarcinoma was higher than that in patients with squamous cell carcinoma and small cell carcinoma,the level of serum SCC-Ag was lower than that in patients with squamous cell carcinoma,and the levels of serum SCC-Ag and CYFRA21-1 were higher than those in patients with small cell carcinoma,and the differences were statistically significant(P<0.05).The serum levels of CEA,SCC-Ag,and CYFRA21-1 in patients with squamous cell carcinoma were higher than those in patients with small cell carcinoma,and the differences were statistically significant(P<0.05).The sensitivity,specificity,positive predictive value,and negative predictive value of the combined detection of CEA,SCC-Ag and CYFRA21-1 in the diagnosis of lung cancer were 98.04%,95.00%,95.24%,and 97.94%,respectively,which were higher than those of the three indicators each alone.Conclusion The serum levels of CEA,SCC-Ag,and CYFRA21-1 were up-regulation in lung cancer patients.The combined detection of t

关 键 词：肺癌 癌胚抗原 鳞状细胞癌抗原 细胞角质蛋白19片段抗原21-1 

分 类 号：R734.2[医药卫生—肿瘤]