层粘连蛋白对乙肝病毒感染相关肝癌患者术后复发及预后状况的效果分析  

Effect of Laminin on Postoperative Recurrence and Prognosis of Patients with Hepatitis B Virus Infection Related Liver Cancer

作　　者：易爱芬 高明[2] YI Ai-fen;GAO Ming(Fourth Department of Liver,Fifth People's Hospital,Anyang 455000,Henan Province,China;Department of Oncology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,Henan Province,China)

机构地区：[1]河南省安阳市第五人民医院肝四科,河南安阳455000 [2]郑州大学第一附属医院肿瘤科,河南郑州450000

出　　处：《罕少疾病杂志》2022年第9期41-42,56,共3页Journal of Rare and Uncommon Diseases

基　　金：绿茶主成分EGCG抑制卵巢的机制研究(21A320072)。

摘　　要：目的分析在乙肝病毒感染相关肝癌患者术后复发以及预后状况中层粘连蛋白发挥的作用和影响。方法回顾性方式展开研究,研究时段为2017年1月至2018年12月,将我院乙肝病毒感染相关肝癌患者100例予以选取,将所有对象采集肝部组织标本,且借助免疫组化法对肝癌组织中层的粘连蛋白表达实施检测,将癌旁组织、肝癌、良性肝病组织中层的粘连蛋白表达展开观察和对比。结果肝窦和新生血管中的层粘连蛋白阳性率较高(60.00%),与肝癌组织细胞膜和细胞质中的层粘连蛋白(40.00%)进行对比,统计学成立,P<0.05。在不同病理指标下肿瘤个数一般超过3个,而微卫星灶、血管侵犯等病理下的层粘连蛋白表达率较高,P<0.05。层粘连蛋白阳性表达患者共有73例,给予手术治疗或复发者35例(35/73),复发率占比47.94%;且与层粘连蛋白阴性表达者的术后生存率相较,前者生存率明显较低。结论肝癌组织中分布着层粘连蛋白,且与肝癌患者病理进展程度之间存在直接关系,检验层粘连蛋白效果显著,可帮助临床工作人员有效预测患者术后是否复发。Objective To analyze the role and influence of laminin in postoperative recurrence and prognosis of hepatitis B virus infection related liver cancer patients.Methods The study was carried out in a retrospective manner.The study period was from January 2017 to December 2018.100 patients with liver cancer related to hepatitis B virus infection in our hospital were selected.Liver tissue samples were collected from all subjects,and the expression of laminin in the middle layer of liver cancer tissue was detected by immunohistochemistry.The expression of laminin in adjacent tissues,liver cancer and benign liver disease tissues was observed and compared.Results The positive rate of laminin in hepatic sinuses and neovascularization was higher(60.00%),Compared with laminin(40.00%)in the cell membrane and cytoplasm of liver cancer tissue,Statistics established,P<0.05.Under different pathological indexes,the number of tumors is generally more than 3,The expression rate of laminin was higher in microsatellite lesions and vascular invasion,P<0.05.There were 73 cases with positive expression of laminin,35 cases(35/73)were treated by operation or relapse,The recurrence rate was 47.94%,The survival rate of patients with negative expression of laminin was higher than that of patients with negative expression of laminin,The survival rate of the former was significantly lower.Conclusion laminin is distributed in liver cancer tissues and has a direct relationship with the pathological progress of liver cancer patients.The test of laminin has a significant effect,which can help clinical staff to effectively predict whether the patients relapse after operation.

关 键 词：层粘连蛋白 乙肝病毒感染 肝癌 术后复发 预后状况 

分 类 号：R735.7[医药卫生—肿瘤]