浅谈微量采血法在药物非临床研究中的应用及3R原则的贯彻  

Application of Blood Microsampling and Its Implementation of the 3Rs in Non-clinical Studies of Drugs

作　　者：陈佳琦[1] 吕龙宝[1] 张飞燕 李瑞[1] 李乙江[1] 李丽红[1] 张晓迪[1] CHEN Jiaqi;LÜLongbao;ZHANG Feiyan;LI Rui;LI Yijiang;LI Lihong;ZHANG Xiaodi(Kunming Institute of Zoology,Chinese Academy of Sciences,Kumming 650223,China)

机构地区：[1]中国科学院昆明动物研究所,昆明650223

出　　处：《实验动物与比较医学》2022年第4期306-312,共7页Laboratory Animal and Comparative Medicine

摘　　要：药物开发中的实验动物福利伦理备受关注,如何善待动物已成为一个重要课题。微量采血法(blood microsampling)克服了常规大容量采血方法操作复杂、对动物的伤害大、对啮齿类动物的数量要求高等诸多缺点,在动物福利、科学性和成本方面均有极大优势,其应用被认为是落实3R原则的重要实践。本文介绍微量采血法的最新研究进展以及在非临床研究中应用的优势和挑战,以期推动这项新技术在药物开发领域内更广泛应用。The welfare and ethics of laboratory animals in drug development has attracted increasing attention,and how to treat animals well has become an important topic.Blood microsampling overcomes several disadvantages of conventional large-volume blood sampling methods,such as complex operation,great harm to animals and high requirement on rodent quantity,and has great advantages in animal welfare,scientificity and cost.Therefore,its application is regarded as an important practice to implement the 3Rs.This article reviewed the latest research progress of blood microsampling,and its advantages and challenges in non-clinical studies in order to promote the wider application of this new technique in this field.

关 键 词：微量采血法 药物 非临床 3R原则 

分 类 号：R-332[医药卫生] Q95-33[生物学—动物学]