阿尔茨海默病动物模型的研究进展  

Research Progress in Animal Model of Alzheimer's Disease

作　　者：盛哲津[1] 李利妹 SHENG Zhejin;LI Limei(School of Life Science and Technology,Tongji University,Shanghai 200092,China;Research Center for Translational Medicine,Shanghai East Hospital,School of Medicine,Tongji University,Shanghai 200120,China)

机构地区：[1]同济大学生命科学与技术学院,上海200092 [2]同济大学附属东方医院医学转化平台,上海200120

出　　处：《实验动物与比较医学》2022年第4期342-350,共9页Laboratory Animal and Comparative Medicine

摘　　要：阿尔茨海默病(Alzheimer's disease,AD)是最常见的老年性神经退行性疾病之一,严重威胁着老年人的健康。目前被批准用于治疗AD的药物只能缓解AD的症状,不能治愈AD或阻止其恶化。近40年来,虽然AD的治疗方法层出不穷,包括阻止脑淀粉样蛋白沉积或清除已有淀粉样蛋白斑块的化合物,但是它们的临床疗效并不显著。因此,需要更多的基础和临床研究来深入探讨AD疾病生物学机制。实验动物模型不仅对AD发病机制的研究,还对AD药物的开发都非常重要。本综述从AD病理组织学特征和遗传因素出发,论述已有的AD动物模型以及其评价方法。Alzheimer's disease(AD)is one of the most common neurodegenerative diseases,which seriously affects the health of the elderly people.The drugs currently approved for the treatment of AD can only reduce the symptoms severity of AD,but can't cure AD or prevent the deterioration of AD.Over the past 40 years,there have been numerous treatments for AD,including compounds that prevent amyloid deposition in the brain or remove existing amyloid plaques,but their clinical curative effects are not significant.Therefore,more basic and clinical studies are needed to improve our understanding of the biological mechanism of AD.Experimental animal models are very important not only for the study of the pathogenesis of AD,but also for the development of AD drugs.This paper reviewed the main histopathological characteristics,genetic factors,the current animal models and model evaluation of AD.

关 键 词：阿尔茨海默病 动物模型 病理组织学特征 淀粉样蛋白 评价 

分 类 号：R-332[医药卫生] Q95-33[生物学—动物学]