Revealing the Mysterious Veil of Prion Diseases Under the Framework of China CDC  

作　　者：Xiaoping Dong 

机构地区：[1]State Key Laboratory for Infectious Disease Prevention and Control,NHC Key Laboratory of Medical Virology and Viral Diseases,National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing,China [2]Center for Biosafety Mega-Science,Chinese Academy of Sciences,Wuhan City,Hubei Province,China [3]China Academy of Chinese Medical Sciences,Beijing,China [4]Shanghai Institute of Infectious Disease and Biosafety,Shanghai Municipality,China

出　　处：《China CDC weekly》2022年第33期721-722,共2页中国疾病预防控制中心周报（英文）

摘　　要：Prion disease(PrD)or transmissible spongiform encephalopathy(TSE)is a group of transmissible and fatal neurodegenerative diseases affecting humans and many animal species.Clinically,PrD,either in humans or in animals,has been documented for more than hundreds of years,e.g.,scrapie in the early 18th century and human Creutzfeldt-Jakob disease(CJD)in the early 20th century(1–2).However,the hypothesis and conception of“prions”have been gradually accepted only since the 1980s.As an unconventional infectious agent without nucleic acids,the principle of the“prion”is unsolved conformational changes from host normal membrane protein PrPc to abnormal pathogenic scrapie-like prion protein(PrP^(Sc))((3).The hypothesis of the prion concept mostly explains the pathogenesis of PrD;however,there are still many gaps that need to be filled.More importantly,“prion theory”opens a completely new window in biology,possibly highlighting a new type of life.

关 键 词：SPECIES HYPOTHESIS hundreds 

分 类 号：S852.659.7[农业科学—基础兽医学] R74[农业科学—兽医学]