Amyloid-β(Aβ)and tau,the two hallmark proteins associated with Alzheimer’s disease(AD),exhibit distinct toxic effects but also interact synergistically within the disease pathology.The prevailing theory in AD patho...
supported by the Massachusetts General Hospital Scientific Projects to Accelerate Research and Collaboration (SPARC) award;Cure Alzheimer’s Fund (to CZ);the National Institutes of Health (NIH),including R01NS102190,RF1NS120947,and R01HL161253 (to MBW),RF1NS120947 (to RJT)。
Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primari...
The increasing interest in the study of spontaneous(SY)and contagious yawning(CY)was so far focused on several taxa,especially primates.Here,we focused on SY and CY in horses,a suitable species due to their complex so...
supported by the State Key Program of National Natural Science Foundation of China(Grant No.32030068);the“Lump-sum System”Project of Chongqing Talent Plan(Grant No.cstc2022ycjh-bgzxm0204).
The island rule,a general pattern of dwarfism in large species to gigantism in small species on islands relative to mainland,is typically seen as a macroevolutionary phenomenon.However,whether the ecological processes...
The subject is the thermodynamics of dark energy. Thermodynamically, the ratio of dark energy to CMR temperature has the units of entropy, has a well-defined numerical value at every moment of cosmological history, an...
The subject is the thermodynamics of dark matter, the Helmholtz free energy. The method of fluctuations leads to an estimate of the mass of a dark matter particle. The picture that emerges is that of a small-mass, deg...
The subject is the mass of the three dominant, equilibrium cosmological objects: the irregular galaxy (dwarf), the regular galaxy (Hubble’s “tuning fork”), and the galactic cluster. The standard ΛCDM theory and a ...
The developmental coordination disorder(DCD)is characterized by an impaired motor coordination skill for age impacting day-life motor activities and academic achievement of children.DCD has been classified as neurodev...
Project supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant Nos.XDB0500302 and LSKJ202300305)。
We derive the transport equations from the Vlasov–Fokker–Planck equation when the velocity space is spherically symmetric.The Shkarofsky's form of Fokker–Planck–Rosenbluth collision operator is employed in the Vla...
Botulinum toxin(BT)injections to the glabellar region are emerging as a promising investigational treatment for multiple mental health conditions.By paralyzing the muscles involved in frowning,this intervention is pos...