Exploring the effect of glabellar Botulinum toxin injections on symptoms of anxiety and depression:A pilot study from a cosmetic patient population  

作　　者：Michael K.Wolfea Arisa Ortiz Rona Z.Silkiss 

机构地区：[1]Department of Psychiatry,University of California,350 Dickinson St,Ste 3-325,San Diego,CA 92103,USA [2]Department of Dermatology,University of California,8899 University Center Ln,Ste 350,San Diego,CA 92122,US [3]Silkiss Eye Surgery,40029th St,Ste 315,Oakland,CA 94609,USA

出　　处：《Journal of Dermatologic Science and Cosmetic Technology》2024年第4期74-78,共5页皮肤科学与化妆品技术期刊(英文)

摘　　要：Botulinum toxin(BT)injections to the glabellar region are emerging as a promising investigational treatment for multiple mental health conditions.By paralyzing the muscles involved in frowning,this intervention is postulated by the facial feedback hypothesis to reduce the intensity of negative affective states and has a growing body of evidence for treating major depression.However,applications to other psychiatric conditions have been relatively unexplored.This is the first study to our knowledge to examine the effect of glabellar BT on generalized anxiety.By tracking GAD-7 scores of a cosmetic population before and after receipt of glabellar BT,we observed a statistically significant decrease of anxious symptoms among patients who entered the study with a baseline level of clinical anxiety.Though more research is needed,our results suggest glabellar BT has the potential to improve symptoms of mild to moderate generalized anxiety.

关 键 词：Botulinum toxin Generalized anxiety disorder Glabellar injections Facial feedback hypothesis Neuromodulatory treatments 

分 类 号：R749.7[医药卫生—神经病学与精神病学]