Characteristics of Different Types of Prion Diseases—China’s Surveillance  

作　　者：Qi Shi Cao Chen Kang Xiao Wei Zhou Chen Gao Liping Gao Jun Han Jichun Wang Xiaoping Dong 

机构地区：[1]State Key Laboratory for Infectious Disease Prevention and Control,NHC Key Laboratory of Medical Virology and Viral Diseases,National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing,China [2]China Academy of Chinese Medical Sciences,Beijing,China [3]Center for Biosafety Mega-Science,Chinese Academy of Sciences,Wuhan City,Hubei Province,China [4]Division of Science and Technology,Chinese Center for Disease Control and Prevention,Beijing,China [5]Shanghai Institute of Infectious Disease and Biosafety,Shanghai Municipality,China

出　　处：《China CDC weekly》2022年第33期723-728,共6页中国疾病预防控制中心周报（英文）

基　　金：Supported by National Key R&D Program of China(2020YFE0205700);SKLID Development Grant(2021SKLID101,2021SKLID503,2021SKLID504);National Natural Science Foundation of China(81772197,81630062,81401670).

摘　　要：This report briefly described the establishment and implementation of national surveillance for human prion disease(PrD)in China.Reported cases came from Chinese surveillance network for PrD.Immunohistochemistry,Western blot,enzyme-linked immunosorbent assay(ELISA),Polymerase Chain Reaction(PCR),and real-time quaking-induced conversion(RT-QuIC)tests were used for the samples of brain,cerebrospinal fluid(CSF),and blood.Diagnosis standard for the PrDs is based on the National Commission of Health(WS/T 562-2017).The study summarized major epidemiological,clinical and laboratory features of more than 2,100 diagnosed different types of Chinese PrD cases.Sporadic Creutzfeldt-Jacob disease(sCJD)is the predominant type of PrD(88.7%).19 different genotypes of genetic PrDs(gPrDs)were identified,accounting for about 11.3%of all PrDs,revealing ethno-relationships.No iatrogenic CJD(iCJD)and variant CJD(vCJD)was identified.The characteristics of different types of sCJD in China showed similar features as those reported globally,but gPrDs showed an obvious ethnorelationship.

关 键 词：IMMUNOSORBENT CASES CLINICAL 

分 类 号：R18[医药卫生—流行病学]