维持治疗方案改善多发性骨髓瘤患者的生存与预后  

Maintenance therapy improves survival and outcome in patients with multiple myeloma

作　　者：徐肖飞 叶杏浓[2] 章澜 王圣洁 金珂熠 陈丹 郑艳 朱晓琼 吴偲 金静霞 黄健 XU Xiaofei;YE Xingnong;ZHANG Lan;WANG Shengjie;JIN Keyi;CHEN Dan;ZHENG Yan;ZHU Xiaoqiong;WU Cai;JIN Jingxia;HUANG Jian(Department of Hematology,the Fourth Affiliated Hospital Zhejiang University School of Medicine,Zhejiang Yiwu 322000,China;Department of Hematology,the First Affiliated Hospital Zhejiang University School of Medicine,Zhejiang Hangzhou 310003,China)

机构地区：[1]浙江大学医学院附属第四医院血液内科,浙江义乌322000 [2]浙江大学医学院附属第一医院血液科,浙江杭州310003

出　　处：《现代肿瘤医学》2022年第17期3196-3199,共4页Journal of Modern Oncology

基　　金：浙江省基础公益研究项目(编号:LGF21H080003);浙江省金华市科技公益重点项目(编号:2020XG-29,2020-3-011);浙江省金华市一类医学重点学科(编号:2019-2022);浙江省义乌市医学重点学科项目(编号:2018-2021);浙江省义乌市浙大四院院士工作站(编号:2019-)。

摘　　要：目的:分析多发性骨髓瘤(multiple myeloma,MM)患者维持治疗及方案与无进展生存期(PFS)、总生存期(OS)的联系,为临床指导治疗。方法:回顾性分析2015年03月至2020年09月在我院住院治疗的所有MM患者,总结其随访结果,分析是否维持治疗以及维持治疗方案对PFS以及OS的影响。结果:维持治疗的患者PFS与OS均优于不维持治疗者(P=0.000,P=0.002)。以来那度胺为主的维持治疗方案疗效最佳(PFS:P=0.000,OS:P=0.005)。单因素分析结果显示MM ISS分期与PFS有关(P=0.040),多因素分析结果提示MM ISS分期和是否维持治疗及维持治疗方案均对PFS有显著影响(P=0.033,P=0.017,P=0.027),是否维持治疗对OS有影响(P=0.016)。结论:维持治疗有利于MM患者生存。以来那度胺为主的维持治疗方案疗效佳,可作为首选。Objective:To investigate progression free survival(PFS)and overall survival(OS)of maintenance therapy in patients with multiple myeloma(MM).Methods:All patients with MM who were hospitalized in our hospital were retrospectively analyzed from March 2015 to September 2020.Results:The PFS and OS of maintenance treatment were better than those of no maintenance treatment(P=0.000,P=0.002).Lenalidomide as maintenance treatment was the most effective(PFS:P=0.000,OS:P=0.005).Univariate analysis showed that ISS stage was associated with PFS(P=0.040).Multivariate analysis showed that ISS stage,maintenance treatment and maintenance treatment plan had significant effect on PFS(P=0.033,P=0.018,P=0.010),and maintenance treatment had effect on OS(P=0.016).Conclusion:Maintenance therapy is beneficial to the survival of MM patients.Lenalidomide as maintenance therapy is effective and can be used as the first choice.

关 键 词：多发性骨髓瘤 维持治疗 来那度胺 

分 类 号：R733.3[医药卫生—肿瘤]