岩舒复方苦参注射液联合羟考酮缓释片在三维适形放射治疗肺癌骨转移疼痛中的临床价值分析  

Clinical value of compound Kushen injection combined with oxycodone sustained-release tablets in three-dimensional conformal radiotherapy for bone metastasis pain of lung cancer

作　　者：陈雅 孙宏新 段铮[3] 蒋士卿 索丹风[4] Chen Ya;Sun Hongxin;Duan Zheng;Jiang Shiqing;Suo Danfeng(Department of Respiratory,Ninth People's Hospital of Zhengzhou,Zhengzhou 450000,China;Department of Oncology,The First Affiliated Hospital of Henan University of CM,Zhengzhou 450000,China;Department of Oncology,Henan Provincial Hospital of Traditional Chinese medicine,Zhengzhou 450000,China;Department of Oncology,The Fifth Affiliated Hospital of Zhengzhou,Zhengzhou 450000,China)

机构地区：[1]郑州市第九人民医院呼吸科,郑州450000 [2]河南省中医药大学第一附属医院肿瘤科,郑州450000 [3]河南省中医院肿瘤科,郑州450000 [4]郑州大学第五附属医院肿瘤科,郑州450000

出　　处：《中国临床实用医学》2022年第3期23-27,共5页China Clinical Practical Medicine

基　　金：河南省科技攻关计划项目(182102310286)。

摘　　要：目的探究岩舒复方苦参注射液联合羟考酮缓释片在三维适形放射治疗(3D-CRT)治疗肺癌骨转移疼痛中的临床价值。方法本研究为前瞻性研究,选取2019年1月至2020年12月郑州市第九人民医院呼吸科收治的88例肺癌骨转移疼痛患者,男42例,女46例,年龄(49.72±12.33)岁,年龄范围为34~73岁。采用随机数表法将患者随机分为单药治疗组与联合治疗组,每组44例。两组患者均对肺癌骨转移灶采用3D-CRT,单药治疗组给予羟考酮缓释片,联合治疗组予羟考酮缓释片联合岩舒复方苦参注射液治疗,比较两组患者的临床治疗效果、疼痛程度、不良反应及生活质量。结果联合治疗组患者治疗有效率[90.9%(40/44)]高于单药治疗组[75.0%(33/44)],差异有统计学意义(P<0.05)。联合治疗组治疗后1周[(5.58±1.33)分]、2周[(5.09±1.24)分]、3周[(4.19±1.34)分]和4周的视觉模拟评分法(VAS)评分[(3.68±0.74)分]均低于单药治疗组[(6.25±1.32)分、(5.67±1.31)分、(4.94±1.35)分、(4.04±0.79)分],差异有统计学意义(P<0.05)。联合治疗组患者不良反应发生情况少于单药治疗组,差异有统计学意义(P<0.05)。治疗前,两组患者的生活质量比较,差异无统计学意义(P>0.05)。治疗后,两组患者的生活质量均高于治疗前,且联合治疗组患者的生活质量高于单药治疗组,差异有统计学意义(P<0.05)。结论岩舒复方苦参注射液联合羟考酮缓释片在3D-CRT治疗肺癌骨转移疼痛患者的临床治疗过程中起到了确切的治疗效果,可一定程度上缓解患者的疼痛程度,降低不良反应发生率,对患者的生活质量起到改善作用,值得在临床中推广应用。Objective To explore the clinical value of compound Kushen injection combined with oxycodone sustained-release tablets in the three-dimensional conformal radiotherapy(3D-CRT)for bone metastasis pain of lung cancer.Methods This article was a prospective study.Totally 88 patients with bone metastasis pain of lung cancer who were treated in department of respiratory medicine of the hospital were selected between January 2019 and December 2020,including 42 males and 46 females,aged(49.72±12.33)years old,ranging from 34 to 73 years old.The patients were randomly divided into the monotherapy group and the combined therapy group by the random number table method,with 44 cases in each group.Both groups were treated with 3D-CRT for bone metastasis of lung cancer,and the monotherapy group was given oxycodone sustained-release tablets while the combined therapy group was given oxycodone sustained-release tablets combined with compound Kushen injection on the basis of the monotherapy group.Clinical treatment effect,pain degree,adverse reactions and quality of life were compared between the two groups of patients.Results The effective rate of treatment of[90.9%(40/44)]in the combined therapy group was higher than[75.0%(33/44)]in the monotherapy group,with statistically statistical differences(P<0.05).The visual analogue scale(VAS)scores in the combined therapy group at 1 week,2 weeks,3 weeks and 4 weeks after treatment were[(5.58±1.33)points,(5.09±1.24)points,(4.19±1.34)points and(3.68±0.74)points],which were lower than[(6.25±1.32)points,(5.67±1.31)points,(4.94±1.35)points,(4.04±0.79)points]in the monotherapy group,with statistically statistical differences(P<0.05).The occurrence of adverse reactions in the combined therapy group was less than that in the monotherapy group,with statistically statistical differences(P<0.05).Before treatment,there were no statistical differences in the quality of life scores between the two groups(P>0.05).After treatment,the quality of life scores in the two groups of patients were hig

关 键 词：岩舒复方苦参注射液 羟考酮缓释片 三维适形放射治疗 肺癌骨转移疼痛 

分 类 号：R734.2[医药卫生—肿瘤]