胎儿单脐动脉与染色体异常的关系及妊娠结局影响评价  

The relationship between fetal single umbilical artery and chromosomal abnormalities and evaluation of the influence on pregnancy outcome

作　　者：杨倩倩 夏庆华 Yang Qianqian;Xia Qinghua(Maternal and Child Health Hospital of Dongchangfu District,Liaocheng Shandong,252000,China)

机构地区：[1]山东省聊城市东昌府区妇幼保健院,山东聊城252000

出　　处：《中外女性健康研究》2022年第13期10-12,共3页Women＇s Health Research

摘　　要：目的:探究胎儿单脐动脉与染色体异常的关系及对妊娠结局的影响。方法:将2018年8月至2020年7月本院进行产前诊断的单脐动脉疾病孕妇50例作为观察组,将同期脐带结构正常孕妇50例作为对照组进行研究。对两组患者实施染色体检查,并观察其妊娠结局。对比两组孕妇脐带血流异常发生情况、合并畸形发生情况、染色体异常情况、妊娠结局情况及观察组孕妇合并胎儿畸形与染色体异常的关系。结果:观察组S/D比值异常发生率为28.00%、RI比值异常发生率为24.00%、合并畸形发生率为38.00%、染色体异常发生率为16.00%、剖宫产发生率为26.00%、引产发生率为22.00%、早产发生率为18.00%,均高于对照组,差异具有统计学意义(χ^(2)=5.263、4.762、23.457、6.658、4.336、5.316、7.814,P均<0.05)。观察组、对照组胎儿生长受限发生率分别为6.00%、4.00%,低出生体质量儿发生率分别10.00%、12.00%,组间差异无统计学意义(χ^(2)=0.211、0.102,P=0.646、0.749)。观察组中,单脐动脉合并胎儿畸形孕妇染色体异常发生率为36.84%,高于单脐动脉无畸形(χ^(2)=9.905,P=0.002)。结论:胎儿单脐动脉的发生与染色体异常呈正相关,且合并畸形时染色体异常的发生率可进一步增加,导致不良妊娠结局的发生率也随之增加,因此,妊娠期间应按规定进行产检,出现异常情况有必要进行染色体产前诊断,以提高新生儿的质量。Objective:To explore the relationship between fetal single umbilical artery and chromosomal abnormalities and its influence on pregnancy outcome.Methods:Fifty pregnant women with single umbilical artery disease diagnosed prenatally in our hospital from August 2018 to July 2020 were taken as the observation group,and 50 pregnant women with normal umbilical cord structure during the same period were taken as the control group.Chromosome examinations were performed on the two groups of patients and their pregnancy outcomes were observed.The occurrence of abnormal umbilical cord blood flow,combined abnormalities,chromosomal abnormalities,pregnancy outcome,and the relationship between the observation group of pregnant women combined with fetal abnormalities and chromosomal abnormalities were compared.Results:The abnormal S/D ratio,RI ratio,combined malformations,chromosomal abnormalities,cesarean section,induced labor,and preterm birth in the observation group were all higher than those in the control group,with statistically significant differences(χ^(2)=5.263,4.762,23.457,6.658,4.336,5.316,7.814,all P<0.05).The incidence of fetal growth restriction was 6.00%in the observation group,4.00% in the control group,and 10.00% in the low birth weight infants,respectively,with no statistically significant difference between the two groups(χ^(2)=0.211,0.102,P=0.646,0.749).In the observation group,the incidence of chromosomal abnormalities in pregnant women with single umbilical artery combined with fetal malformation was 36.84%,higher than that without single umbilical artery malformation(χ^(2)=9.905,P=0.002).Conclusion:The occurrence of fetal single umbilical artery is positively correlated with chromosomal abnormalities,and the incidence of chromosomal abnormalities can be further increased when combined with malformations,leading to an increase in the incidence of adverse pregnancy outcomes.Therefore,the obstetric examination should be carried out according to regulations during pregnancy.Prenatal diagnosis of chromosom

关 键 词：胎儿单脐动脉 染色体异常 妊娠结局 相关性 

分 类 号：R714[医药卫生—妇产科学]