柴芍六君方治疗61例肝郁脾虚型溃疡性结肠炎的临床探析  

Clinical Analysis on 61 Cases Of Ulcerative Colitis of Liver Depression and Spleen Deficiency Type Treated With Chaishao Liujun Formula

作　　者：苏攀[1] 康毅[1] 李洁[1] 郭桂伶 

机构地区：[1]广西中医药大学第一附属医院,广西南宁530023 [2]南宁市第四人民医院,广西南宁530023

出　　处：《大众科技》2022年第8期68-71,共4页Popular Science & Technology

基　　金：广西卫生和计划生育委员会自筹课题(Z20180531)。

摘　　要：目的:探析柴芍六君方在临床上对肝郁脾虚型溃疡性结肠炎治疗的疗效。方法:研究病例随机分组共计61例,其中31名中药柴芍六君方治疗组和30名美沙拉嗪对照组,对比评价两组药物在治疗该病肝郁脾虚型的治疗效果及不良反应。治疗前后评价两组病例肠镜的粘膜疗效、总体治疗有效率、肠道粘膜病理变化、主要症状及评分、IBDQ评分、患者生存质量和不良药物反应。结果:治疗后柴芍六君方组在总体治疗有效率、肠镜的粘膜疗效、肠道粘膜病理变化均优于美沙拉嗪组(P<0.05);柴芍六君方组在缓解患主要症状及评分上中药优于美沙拉嗪组(P<0.05);治疗后柴芍六君方组在IBDQ评分、患者生存质量上的积分改善明显(P<0.01);两组不良药物反应中药治疗组较低(P<0.05)。结论:在治疗肝郁脾虚型溃疡性结肠炎中药加味柴芍六君治疗疗效显著,能改善患者的生存质量,降低药物不良反应的发生,比单用美沙拉嗪更具优势。Objective: To explore the clinical efficacy of Chaishao Liujun formula in the treatment of ulcerative colitis with liver stagnation and spleen deficiency type. Methods: A total of 61 cases were randomly divided into two groups, including 31 cases in the traditional Chinese medicine Chaishao Liujun formula treatment group and 30 cases in the mesalazine control group. The therapeutic effects and adverse reactions of the two groups in the treatment of liver depression and spleen deficiency type of this disease were compared and evaluated. Before and after treatment, the mucosal curative effect, overall effective rate, pathological changes of intestinal mucosa,main symptoms and scores, IBDQ score, quality of life and adverse drug reactions were evaluated. Results: After treatment, Chaishao Liujun formula group was superior to mesalazine group in the overall therapeutic efficiency, enteroscopic mucosal efficacy, and pathological changes of intestinal mucosa(P<0.05). Chaishao Liujun formula group was superior to mesalazine group in relieving main symptoms and scoring(P<0.05);after treatment, the IBDQ score and quality of life of patients in the Chaishao Liujun formula group were significantly improved(P<0.01);the adverse drug reactions of the two groups were lower in the traditional Chinese medicine treatment group(P<0.05). Conclusion: In the treatment of ulcerative colitis of liver depression and spleen deficiency type, the modified Chaishao Liujun has significant curative effect. It can improve the quality of life of patients and reduce the occurrence of adverse drug reactions. It has more advantages than mesalazine alone.

关 键 词：肝郁脾虚型 溃疡性结肠炎 加味柴芍六君 美沙拉嗪 临床研究 

分 类 号：R574[医药卫生—消化系统]