血凝酶与生长抑制素联合奥美拉唑治疗急性上消化道出血患者的疗效及安全性  

Efficacy and safety of hemocoagulase,somatostatin and omeprazole in the treatment of acute upper gastrointestinal bleeding

作　　者：程习学 CHENG Xixue(Department of Emergency,Shenzhen Junlong Hospital,Shenzhen,Guangdong,518110,China)

机构地区：[1]深圳军龙医院急诊科,广东深圳518110

出　　处：《当代医学》2022年第22期87-89,共3页Contemporary Medicine

摘　　要：目的探究血凝酶、生长抑素联合奥美拉唑治疗急性上消化道出血患者的疗效及安全性。方法选取2019年1月至2021年1月本院收治的62例急性上消化道出血患者作为研究对象,按照随机数字法分为对照组(奥美拉唑)和观察组(血凝酶+生长抑素+奥美拉唑),每组31例。比较两组临床疗效、不良反应发生率、凝血功能指标。结果观察组治疗总有效率为96.77%,高于对照组的80.65%,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。用药前,两组凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)水平比较差异无统计学意义;用药后,两组PT水平均低于用药前,且观察组低于对照组,观察组APTT水平低于用药前(P<0.05),对照组治疗前后APTT水平比较差异无统计学意义。结论血凝酶、生长抑素联合奥美拉唑治疗急性上消化道出血疗效确切,且未增加不良反应发生率,可有效改善患者凝血功能,值得临床推广应用。Objective To investigate the efficacy and safety of hemocoagulase,somatostatin and omeprazole in the treatment of acute upper gas-trointestinal bleeding.Methods 62 patients with acute upper gastrointestinal bleeding admitted to our hospital from January 2019 to January 2021 were selected as the research subjects.They were divided into controls group(omeprazole)and observation group(hemagglutinin+somatostatin+omeprazole according to the random number method),with 31 cases in each group,the clinical efficacy,incidence of adverse reactions,and coagula-tion function indexes between the two groups were compared.Results The total effective rate in the observation group was 96.77%,which was high-er than 80.65%in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Before treatment,there was no significant difference in prothrombin time(PT)and activated partial throm-boplastin time(APTT)levels between the two groups;after treatment,PT levels were lower than before treatment,and the observation group was lower than the control group,and the APTT level in the observation group was lower than before treatment(P<0.05),there was no significant differ-ence in APTT levels before and after treatment in the control group.Conclusion Hemocoagulase,somatostatin combined with omeprazole is effec-tive in the treatment of acute upper gastrointestinal bleeding without increasing the incidence of adverse reactions,it can effectively improve the coag-ulation function of patients and is worthy of clinical application.

关 键 词：急性上消化道出血 奥美拉唑 血凝酶 生长抑素 凝血功能 

分 类 号：R573.2[医药卫生—消化系统]