脂代谢重编程在前列腺癌中的研究进展  

Research Progress of Lipid Metabolism Reprogramming in Prostate Cancer

作　　者：曾凯 刘继红[1] 李强[2] 王勤章 ZENG Kai;LIU Jihong;LI Qiang;WANG Qinzhang(Department of Urology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Department of Urology,The First Affiliated Hospital of Medical College,Shihezi University,Shihezi 835215,China)

机构地区：[1]华中科技大学同济医学院附属同济医院泌尿外科,武汉430030 [2]石河子大学医学院第一附属医院泌尿外科,石河子835215

出　　处：《肿瘤防治研究》2022年第8期774-779,共6页Cancer Research on Prevention and Treatment

基　　金：新疆生产建设兵团科技计划支撑项目(2021AB032)。

摘　　要：代谢重编程在肿瘤的发生发展过程中扮演着重要角色,为肿瘤细胞的生命活动提供了必要的物质基础,并对肿瘤的生物学行为起促进作用。代谢重编程可引起肿瘤细胞中氨基酸、葡萄糖和脂肪酸的代谢模式发生改变,是肿瘤的标志性特征之一。目前发现大多数肿瘤倾向利用糖酵解产生的Warburg效应为自身供能,而研究表明前列腺癌细胞更依赖脂肪酸氧化途径进行代谢重编程获取能量物质。因此,深度掌握脂质代谢关键酶和相关调控基因间的关系,对前列腺癌早期诊断、精准靶向治疗及获得更好的疾病预后具有重要意义。Metabolism reprogramming plays an important role in the process of tumor occurrence and development,and provides the necessary material basis for tumor cells.It can change the metabolic patterns of amino acids,glucose and fatty acids in tumor cells,which is one of the hallmark features of tumors.At present,it is shown that most tumors tend to take advantage of glycolysis for energy resource.In contrast,studies have shown that prostate cancer cells dependent more on the fatty acid oxidation pathway for metabolic reprogramming to obtain energy substances.Therefore,it is of great significance to understand the relation between key enzymes of lipid metabolism and regulatory genes for early diagnosis,targeted treatment and better prognosis of prostate cancer.

关 键 词：前列腺癌 代谢重编程 脂质代谢 脂肪酸氧化 

分 类 号：R737.25[医药卫生—肿瘤]