线粒体DNA在消化系恶性肿瘤发生发展中的作用机制研究进展  

Research Progress on Mechanism of Mitochondrial DNA in Occurrence and Development of Digestive System Malignant Tumors

作　　者：王凌霄 王颖佳 杨健[1] 李耀平[1] WANG Lingxiao;WANG Yingjia;YANG Jian;LI Yaoping(The Fifth Clinical Medical College of Shanxi Medical University,Taiyuan 030012,China)

机构地区：[1]山西医科大学第五临床医学院,太原030012

出　　处：《肿瘤防治研究》2022年第8期838-842,共5页Cancer Research on Prevention and Treatment

基　　金：山西省应用基础研究计划(201901D111431,202103021224379);山西省研究生教育创新计划(2021Y399)。

摘　　要：线粒体DNA(mt-DNA)是核外遗传信息的重要载体。近期研究结果显示,mt-DNA与多种恶性肿瘤的发生、转移密切相关,且可用于癌症的早期诊断和靶向治疗。因此进一步研究mt-DNA在消化系恶性肿瘤中的作用机制,对于筛选和鉴定肿瘤分子标志物用于抗肿瘤药物靶点、癌症诊断及预后分析均有重要的临床意义。本文对近年mt-DNA与消化系恶性肿瘤的潜在联系、临床应用及治疗靶点的研究进展进行综述。Mitochondrial DNA(mt-DNA)is an important carrier of extranuclear genetic information.Recent research results show that mt-DNA is closely related to the occurrence and metastasis of various malignant tumors,and can be used for early diagnosis and targeted therapy of cancer.Therefore,further research on the mechanism of mt-DNA in digestive system malignant tumors has important clinical significance for screening and identifying tumor molecular markers for anti-tumor drug targets,cancer diagnosis and prognosis analysis.This article reviews the research progress on the potential relationship,clinical application and therapeutic targets of mt-DNA and digestive system malignancies.

关 键 词：mt-DNA 消化系恶性肿瘤 癌症 早期检测 临床转化应用 

分 类 号：R735[医药卫生—肿瘤]