后腹腔镜肾癌根治术对患者应激指标、炎症介质及疼痛因子表达及睡眠质量的影响研究  

Effect of Retroperitoneal Laparoscopic Radical Nephrectomy on the Expression of Stress Indexes,Inflammatory Factors and Pain Factors in Patients with Renal Cell Carcinoma

作　　者：赵治国 叶玉花 ZHAO Zhiguo;YE Yuhua(Department of Urology,Baiyun Hospital Affiliated to Guizhou Medical University,Guiyang 550014,China)

机构地区：[1]贵州医科大学附属白云医院泌尿外科,贵阳550014

出　　处：《世界睡眠医学杂志》2022年第7期1195-1198,共4页World Journal of Sleep Medicine

摘　　要：目的:探讨后腹腔镜肾癌根治术对患者术后应激指标、炎症介质及疼痛评分和睡眠质量的影响。方法:选取2018年1月至2022年1月贵州医科大学附属白云医院收治的肾癌患者144例作为研究对象,随机分为观察组和对照组,每组72例。观察组采用后腹腔镜肾癌根治术治疗,对照组采用开放式肾癌根治术治疗,观察和比较2组患者应激指标、炎症介质指标、疼痛指标和肿瘤标志物指标。结果:手术后第3天,观察组患者的白细胞数、皮质醇、FT3、FT4、CRP等应激指标均优于对照组,差异均有统计学意义(均P<0.05);观察组患者的IL-2、IL-10、IL-13、IL-1β、IL-6、IL-12等炎症介质指标均优于对照组,差异均有统计学意义(均P<0.05);观察组患者的VAS评分和PSQI评分均优于对照组,差异均有统计学意义(均P<0.05);观察组患者的CA125肿瘤标志物指标优于对照组,差异有统计学意义(P<0.05)。结论:与传统肾癌根治术比较,后腹腔镜肾癌根治术能够更好地降低患者应激反应和炎症反应指标,改善疼痛症状和睡眠质量,有利于其术后康复,是临床治疗肾癌的理想方案之一。Objective:To investigate the differences of postoperative stress indexes,inflammatory factors and pain score and sleep quality.in patients with renal cancer treated with traditional open surgery and retroperitoneal laparoscopic radical nephrectomy.Methods:From January 2018 to January 2022,144 patients with renal cancer treated in Baiyun Hospital Affiliated to Guizhou Medical University were selected as the research object.The patients were randomly divided into the observation group(treated with retroperitoneal laparoscopic radical nephrectomy)and the control group(treated with open radical nephrectomy),with 72 patients in each group.The indexes of stress,inflammatory factors,pain and tumor markers were observed and compared between the two groups.Results:On the third day after operation,the stress indexes such as leukocyte count,cortisol,FT3,FT4 and CRP in the observation group were better than those in the control group,and the difference was statistically significant(P<0.05);IL-2,IL-10,IL-13 and IL-1 in the observation groupβ、The indexes of inflammatory factors such as IL-6 and IL-12 were better than those in the control group,and the difference was statistically significant(P<0.05);The VAS score and PSQI score of the observation group were better than those of the control group,and the difference was statistically significant(P<0.05);The indexes of CA125 tumor markers in the observation group were better than those in the control group,and the difference was statistically significant(P<0.05).Conclusion:Compared with the traditional open surgical treatment,retroperitoneal laparoscopic radical nephrectomy for renal cancer patients can reduce the state of stress reaction and inflammatory reaction,improve the pain situation,and is conducive to the postoperative rehabilitation of patients.It is one of the ideal schemes in clinical practice.

关 键 词：后腹腔镜肾癌根治术 应激指标 炎症介质 睡眠质量 

分 类 号：R737.11[医药卫生—肿瘤]