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作 者:王伟佳 唐硕 马应钧 章娜 蒋柳云 张燕 WANG Wei-jia;TANG Shuo;MA Ying-jun;ZHANG Na;JIANG Liu-yun;ZHANG Yan(College of Chemistry and Chemical Engineering,Hunan Normal University,Changsha 410081,China)
机构地区:[1]湖南师范大学化学化工学院,中国长沙410081
出 处:《湖南师范大学自然科学学报》2022年第4期128-135,共8页Journal of Natural Science of Hunan Normal University
基 金:湖南省大学生创新创业训练计划一般项目(2021083)。
摘 要:纳米羟基磷灰石(n-HA)具有与自然骨类似的无机组分,通常作为聚合物的增强填料,可提高复合材料的机械稳定性,促进与细胞的相互作用,并促进包括干细胞在内的细胞的增殖、黏附和分化。它还可以通过选择性的蛋白质吸附来促进细胞-材料表面的相互作用,一直是骨组织工程的研究热点。本文综述了纳米羟基磷灰石与天然高分子、合成高分子、无机材料以及其他活性因子的复合材料作为骨组织工程支架材料的理化性能及生物学性能的研究现状,并展望了提高n-HA基复合材料性能的几个途径,为制备高性能骨组织工程支架材料提供参考。Nano-hydroxyapatite(n-HA) is usually used as reinforcing fillers for polymers because of the similarity of inorganic components to the natural bone, which can improve the mechanical stability of composites and the interaction with cells and further promote the proliferation, adhesion and differentiation of cells including stem cells. Moreover, it can also promote the interaction between the cell and the material surface through the selective protein adsorption, so that it has always been the research hotspot of bone tissue engineering. This paper summarized the research status for the physical, chemical and biological properties of n-HA-based composites with natural polymers, synthetic polymers, inorganic materials and other active agents as bone tissue engineering scaffolds. Finally, several ways to improve the properties of n-HA-based composites were put forward for the preparation of high-performance bone tissue engineering scaffolds.
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