CT引导下^(125)Ⅰ粒子植入在原发性肝癌经导管动脉化学栓塞后残余病灶治疗中的运用效果  

The application effect of CT-guided^(125)Ⅰseed implantation in the treatment of residual lesions of primary liver cancer after transcatheter arterial chemical embolization

作　　者：徐德国 XU Deguo(Xianning Central Hospital/the First Affiliated Hospital of Hubei University of science and Technology,Xianning,Hubei,437100,China)

机构地区：[1]咸宁市中心医院/湖北科技学院附属第一医院,湖北咸宁437100

出　　处：《当代医学》2022年第20期13-16,共4页Contemporary Medicine

摘　　要：目的探究CT引导下^(125)I粒子植入在原发性肝癌经导管动脉化学栓塞(TACE)后残余病灶治疗中的应用效果。方法选取2018年1月至2021年1月本院收治的120例原发性肝癌患者作为研究对象,所有患者均经TACE后残余病灶治疗中应用CT引导下^(125)I粒子植入,观察患者治疗效果,并比较治疗前和治疗后3个月T淋巴细胞亚群水平及血清肿瘤标志物水平[血清癌胚抗原(CEA)、细胞角蛋白19片段抗原21-1(CYFRA21-1)、鳞状细胞癌相关抗原(SCC-Ag)、糖类抗原125(CA125)]。结果120例患者中,完全缓解2例(1.67%),部分缓解例57(47.50%),无变化46例(38.33%),进展15例(12.50%),疾病控制率为87.50%(105/120)。治疗后3个月,患者CD4^(+)、CD4^(+)/CD8^(+)水平均高于治疗前,CD8^(+)水平低于治疗前(P<0.05);治疗后3个月,患者CD3^(+)水平与治疗前比较差异无统计学意义。治疗后3个月,患者CEA、CYFRA21-1、SCC-Ag、CA125水平均低于治疗前(P<0.05)。结论在原发性肝癌TACE后残余病灶治疗中采用CT引导下^(125)I粒子植入,能有效缓解患者病情,改善免疫功能,并降低血清肿瘤标志物水平。Objective To explore the effect of CT-guided^(125)I seed implantation in the treatment of residual lesions after transcatheter arterial chemical embolization(TACE)of primary liver cancer.Methods A total of 120 patients with primary liver cancer received in our hospital from January 2018 to January 2021 were selected as the research subjects,all patients were treated with CT guided^(125)I seed implantation in the treatment of residual lesions after TACE,and the treatment effect was observed,and the levels of T lymphocyte subsets and serum tumor markers serum carcinoembryonic antigen(CEA),cytokeratin 19 fragment antigen 21-1(CYFRA21-1),squamous cell carcinoma associated antigen(SCC Ag)and carbohydrate antigen 125(CA125)were compared before and 3 months after treatment.Results Among 120 patients,2 had complete remission(1.67%),57 had partial remission(47.50%),46 had no change(38.33%),15 had progressed(12.50%),and the disease control rate was 87.50%(105/120).The CD4^(+),CD4^(+)/CD8^(+)levels of patients treated for 3 months were higher than before treatment,and CD8^(+)levels were lower than before treatment(P<0.05);3 months after treatment,there was no significant difference in CD3+levels compared with before treatment.At the same time,the levels of CEA,CYFRA21-1,SCC-Ag,and CA125 of patients treated for 3 months were lower than before treatment(P<0.05).Conclusion The use of CT-guided^(125)I seed implantation in the treatment of residual lesions of primary liver cancer after TACE can effectively alleviate the patient's condition,improve immune function,and reduce serum tumor marker levels.

关 键 词：原发性肝癌 经导管动脉化学栓塞(TACE) 残余病灶 CT引导 125Ⅰ粒子植入 

分 类 号：R735.7[医药卫生—肿瘤]