替吉奥节拍化疗治疗老年晚期消化道肿瘤的临床疗效  

Study on the clinical effect of seggio metronomic chemotherapy in the treatment of advanced gastrointestinal tumors in the elderly

作　　者：刘芳 LIU Fang(Department of Oncology,Central Hospital of Zaozhuang Mining Group,Zaozhuang,Shandong,277000,China)

机构地区：[1]枣庄矿业集团中心医院肿瘤科,山东枣庄277000

出　　处：《当代医学》2022年第20期30-33,共4页Contemporary Medicine

摘　　要：目的 探讨替吉奥节拍化疗治疗老年晚期消化道肿瘤的临床疗效。方法 回顾性分析2019年2月至2021年2月本院收治的108例老年晚期消化道肿瘤患者的临床资料,按照患者及家属意愿分为常规化疗组(n=50)和节拍化疗组(n=58)。常规化疗组给予替吉奥60 mg治疗,每天2次,连续服用14 d,停药7 d,21 d为1个周期;节拍化疗组给予替吉奥20 mg治疗,每天2次,持续口服治疗。治疗2个周期后,比较两组临床疗效、不良反应发生率和治疗前后血管内皮生长因子(VEGF)、基质金属蛋白酶(MMP)、生命质量评分。结果 两组临床控制率、缓解率比较差异无统计学意义。节拍化疗组骨髓移植、消化道反应和手足综合征Ⅱ级、Ⅲ级占比均低于常规化疗组(P<0.05)。治疗后,两组VEGF、MMP水平均低于治疗前(P<0.05);两组VEGF、MMP水平比较差异无统计学意义。治疗后,节拍化疗组生铭质量评分高于常规化疗组(P<0.05)。结论 替吉奥节拍化疗治疗老年晚期消化道肿瘤的临床疗效与常规化疗无明显差异,治疗效果均显著,安全性高,能提升患者生命质量。Objective To investigate the clinical effect of seggio metronomic chemotherapy in the treatment of elderly patients with advanced gastrointestinal tumors. Methods The clinical data of 108 elderly patients with advanced gastrointestinal tumors admitted to our hospital from February 2019 to February 2021 were retrospectively analyzed, and they were divided into conventional chemotherapy group(n=50) and metronomic chemotherapy group(n=58) according to the wishes of the patients and their families. The conventional chemotherapy group was treated with 60 mg of Sujio, twice a day, 14 d of continuous administration, and the drug was discontinued for 7 d, with 21 d as one cycle;the metronomic chemotherapy group was treated with 20 mg of siggio, twice a day, continuously orally. After 2 cycles of treatment, the clinical efficacy, incidence of adverse reactions, vascular endothelial growth factor(VEGF), matrix metalloproteinase(MMP), and quality of life scores were compared between the two groups before and after treatment. Results There was no significant difference in the clinical control rate and remission rate between the two groups. The proportions of bone marrow transplantation, digestive tract reaction, hand-foot syndrome grade Ⅱ and grade Ⅲ in the metronomic chemotherapy group were lower than those in the conventional chemotherapy group(P<0.05). After treatment, the levels of VEGF and MMP in the two groups were lower than those before treatment(P<0.05), and there was no significant difference in the levels of VEGF and MMP between the two groups.After treatment, the quality of life score in the metronomic chemotherapy group was higher than that in the conventional chemotherapy group(P<0.05). Conclusion There is no significant difference in the clinical efficacy of Sigio metronomic chemotherapy in the treatment of elderly patients with advanced gastrointestinal tumors and conventional chemotherapy. Both treatments have significant effects, high safety, and can improve the quality of life of patients.

关 键 词：替吉奥 节拍化疗 老年晚期消化道肿瘤 生命质量 不良反应 

分 类 号：R735[医药卫生—肿瘤]