The SACT Template:A Human Brain Diffusion Tensor Template for School-age Children  

作　　者：Congying Chu Haoran Guan Sangma Xie Yanpei Wang Jie Luo Gai Zhao Zhiying Pan Mingming Hu Weiwei Men Shuping Tan Jia-Hong Gao Shaozheng Qin Yong He Lingzhong Fan Qi Dong Sha Tao 

机构地区：[1]National Key Laboratory of Cognitive Neuroscience and Learning&IDG/McGovern Institute for Brain Research,Beijing Normal University,Beijing 100875,China [2]Bejing Key Laboratory of Brain Imaging and Connectomics,Beijing Normal University,Bejing 100875,China [3]Center for MRI Research,Academy for Advanced Interdisciplinary Studies,Peking University,Beijing 100871,China [4]Beijing City Key Laboratory for Medical Physics and Engineering,Institute of Heavy lon Physics,School of Physics,Peking University,Beijing 100871,China [5]MeGovern Institute for Brain Research,Peking University,Beijing 100871,China [6]Psychiatry Research Center,Bejing HuiLongGuan Hospital,Peking University,Bejing 100096,China [7]Division of Molecular Neuroimaging,Institute of Neuroscience and Medicine-2,Research Center Julich,52425 Jilich,Germany [8]Institute of Biomedical Engineering and Instrumentation,School of Automation,Hangzhou Dianzi University,Hangzhou 310018,China [9]Brainnetome Center and National Laboratory of Pattern Recognition,Institute of Automation,Chinese Academy of Sciences,Beijing 100190,China

出　　处：《Neuroscience Bulletin》2022年第6期607-621,共15页神经科学通报（英文版）

基　　金：supported by the Beijing Brain Initiative of Beijing Municipal Science&Technology Commission(Z1811001518003);the National Natural Science Foundation of China(31521063);All the authors thank the National Center for Protein Sciences at Peking University for assistance_with brain scanning.The authors thank the"2019 Helmholtz-OCPC-Program for the involvement of postdocs in bilateral collaboration projects"for financial support that enabled this important study,Allthe authors are grateful for the contribution of the participants to the CBD project and the open access to the NKI-Rockiand sample.

摘　　要：School-age children are in a specific development stage corresponding to juvenility,when the white matter of the brain experiences ongoing maturation.Dffusion-weighted magnetic resonance imaging(DWI),especially diffusion tensor imaging(DTI),is extensively used to characterize the maturation by assessing white matter properties in vivo.In the analysis of DWI data,spatial normalization is crucial for conducting inter-subject analyses or linking the individual space with the reference space.Using tensor-based registration with an appropriate diffusion tensor template presents high accuracy regarding spatial normalization.However,there is a lack of a standardized diffusion tensor template dedicated to school-age children with ongoing brain development.Here,we established the school-age children diffusion tensor(SACT)template by optimizing tensor reorientation on high-quality DTI data from a large sample of cognitively normal participants aged 6-12 years.With an age-balanced design,the SACT template represented the entire age range well by showing high similarity to the age-specific templates.Compared with the tensor template of adults,the SACT template revealed significantly higher spatial normalization accuracy and inter-subject coherence upon evaluation of subjects in two different datasets of schoolage children.A practical application regarding the age associations with the normalized DTI-derived data was conducted to further compare the SACT template and the adult template.Although similar spatial patterns were found,the SACT template showed significant effects on the distributions of the statistical results,which may be related to the performance of spatial normalization.Looking forward,the SACT template could contribute to future studies of white matter development in both healthy and clinical populations.The SACT template is publicly available now(tp://igshare com/aricles/dataseu'SACT_.template/14071283).

关 键 词：School-age children Diffusion-weighted MRI Diffusion tensor template Spatial normalization 

分 类 号：R741[医药卫生—神经病学与精神病学]