败酱草及其有效成分抗结直肠癌药理作用机制研究进展  

Research progress on pharmacological mechanism of Herba Patriniae and its active ingredients against colorectal cancer

作　　者：陈慧心 黄莹莹 李子欣[1,2,3] 易丹 张莹[1,2] CHEN Huixin;HUANG Yingying;LI Zixin;YI Dan;ZHANG Ying(First Teaching Hosital of Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China;First Teaching Hosital of Tianjin University of Traditional Chinese Medicine,National Clinical Research Center for Chinese Medicine Acuuncture and Moxibustion,Tianjin 300381,China;Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学第一附属医院,天津300381 [2]国家中医针灸临床医学研究中心,天津300381 [3]天津中医药大学,天津301617

出　　处：《药物评价研究》2022年第7期1435-1439,共5页Drug Evaluation Research

基　　金：国家自然科学基金资助项目(82104553)。

摘　　要：败酱草来源于败酱科草本植物黄花败酱Patrinia scabiosaefolia和白花败酱P.villosa的带根全草,其乙醇提取物在动物体内外实验中均表现出明显的抗结直肠癌作用,抗肿瘤的主要活性成分为黄酮类和皂苷类。败酱草抗结直肠癌药理作用机制主要是抑制结直肠癌细胞增殖并诱导其凋亡,抑制肿瘤血管生成,调控相关蛋白表达,调节信号传导通路,逆转结直肠癌细胞耐药及调节机体免疫功能。对败酱草及其有效成分抗结直肠癌的药理作用机制进行综述,以期为抗结直肠癌新药研发提供参考。Herba Patriniae is a root grass of herbaceous plants Patrinia scabiosaefolia Fisch and P.villosa Juss,the ethanol extract of it showed remarkable anti-cancer effects both in vitro and in vivo,the main active components of anti-tumor are flavonoids and saponins.The pharmacological mechanism of anti-colorectal cancer of the Herba Patriniae is mainly to inhibit the proliferation of colorectal cancer cells and induce their apoptosis,inhibit tumor angiogenesis,regulate the expression of related proteins,regulate signaling pathways,reverse colorectal cancer cell resistance and regulate the body's immune function.The pharmacological mechanism of anti-colorectal cancer of the Herba Patriniae and its active ingredients is reviewed,in order to provide a reference for the research and development of new drugs against colorectal cancer.

关 键 词：败酱草 黄花败酱 白花败酱 结直肠癌 药理作用 作用机制 

分 类 号：R285.5[医药卫生—中药学]