角膜应力-应变指数在圆锥角膜诊断中的价值及CXL术后角膜生物力学参数变化的研究  

Evaluation of two biomechanical stiffness indexes in the diagnosis of eratoconus and their changes after corneal collagen cross-linking surgery

作　　者：刘国英 荆丽丽 李杰 杜显丽 Liu Guoying;Jing Lili;Li Jie;Du Xianli(Eye Institute of Shandong First Medical University,Qingdao Eye Hospital of Shandong First Medical University,State Key Laboratory Cultivation Base,Shandong Provincial Key Laboratory of Ophthalmology,School of Ophthalmology,Shandong First Medical University,Qingdao 266071,China)

机构地区：[1]山东第一医科大学附属眼科研究所山东第一医科大学附属青岛眼科医院山东省眼科学重点实验室-省部共建国家重点实验室培育基地山东第一医科大学眼科学院,青岛266071

出　　处：《中华眼科杂志》2022年第8期584-591,共8页Chinese Journal of Ophthalmology

基　　金：山东第一医科大学学术提升计划(2019ZL001)。

摘　　要：目的探讨角膜应力-应变指数(SSI)对于不同分期或程度的圆锥角膜的诊断效力,以及其与第1次压平硬度(SPA1)在角膜胶原交联术(CXL)后的变化。方法横断面研究及回顾性病例系列研究。纳入2019年7月至2021年8月青岛眼科医院确诊的临床期圆锥角膜(CKC)患者94例(113只眼)作为CKC组,其中男性69例,女性25例,年龄(20.82±4.53)岁;并进一步按疾病程度分为轻(35例,36只眼)、中(36例,40只眼)、重度(33例,37只眼)3个亚组;纳入CKC组56例单眼发病患者的未发病眼作为亚临床期圆锥角膜(SKC)组;纳入健康者91例(91只眼)作为对照组。所有受试眼均行Pentacam角膜地形图和可视化角膜生物力学分析仪检查获取角膜平均曲率(Km)、角膜前表面最大曲率(Kmax)、角膜顶点和距顶点2 mm处的形变幅度比值(DAR)、综合半径(IR)、水平方向Ambrósio相关厚度(ARTH)、角膜中央厚度(CCT)、SPA1及SSI等参数进行比较。另收集CKC组中行CXL术的48例(65只眼)患者资料于术前及术后3、6、12个月分别检查上述参数。采用方差分析、Kruskal-Wallis H检验、配对t检验、受试者操作特征(ROC)曲线、Pearson相关分析等对数据进行分析。结果SKC组的SPA1约为对照组的85.53%(87.92±12.38和102.79±11.74;t=-6.614,P<0.001),而SSI与对照组差异无统计学意义(t=0.105,P=0.916)。CKC组的SPA1约为对照组的52.87%(54.35±14.70和102.79±11.74;t=25.985,P<0.001),SSI约为对照组的67.96%(0.70±0.14和1.03±0.14;t=-15.305,P<0.001)。轻、中、重度亚组的SPA1分别为64.27±12.12、55.22±12.23、43.75±12.33,SSI分别为0.78±0.14、0.71±0.11、0.61±0.09,组间差异均有统计学意义(均P<0.05)。SPA1对SKC具有良好的鉴别力(曲线下面积为0.802),而SSI则无诊断价值(P=0.869);相比SSI,SPA1对不同程度圆锥角膜的鉴别力更高,其中鉴别轻度CKC与SKC的ROC曲线下面积为0.914。对照组、SKC组及CKC组SSI均与SPA1呈正相关(r=0.278,0.368,0.550)、与DAR(r=-0.346,-Objective To evaluate the diagnostic efficacy of stress-strain index(SSI)for different stages or degrees of keratoconus and changes of SSI and stiffness parameter A1(SPA1)after corneal collagen cross-linking(CXL)surgery.Methods Cross-sectional study and retrospective case series study.Ninety-four patients(113 eyes)diagnosed as clinical keratoconus(CKC)in Qingdao Eye Hospital from July 2019 to August 2021 were enrolled in the CKC group,including 69 males and 25 females,aged(20.82±4.53)years,and further divided into subgroups of mild(35 patients,36 eyes),moderate(36 patients,40 eyes)and severe(33 patients,37 eyes)CKC.Fifty-six unaffected eyes of monocular keratoconus patients were enrolled in the subclinical keratoconus(SKC)group.Ninety-one healthy subjects(91 eyes)were recruited as the control group.All subjects were examined by Pentacam topography and Corvis ST measurements to obtain mean keratometry,maximal keratometry,deformation amplitude(DA)ratio at 2 mm,integrated radius(IR),Ambrósio′s relational thickness to the horizontal profile,corneal central thickness,SPA1 and SSI for comparison.Forty-eight CKC patients(65 eyes)underwent CXL surgery,and the above parameters were recorded before and 3,6 and 12 months after operation.Data were analyzed by the ANOVA test,Kruskal-Wallis H test,paired sample test,receiver operating characteristic curves and Pearson correlation.Results The value of SPA1 in the SKC group accounted for 85.53%(87.92±12.38 vs.102.79±11.74;t=-6.614,P<0.001)compared with the control group,but the value of SSI had no difference in the two groups(t=0.105,P=0.916).The value of SPA1 in the CKC group accounted for 52.87%(54.35±14.70 vs.102.79±11.74;t=25.985,P<0.001)compared with the control group.The value of SSI in the CKC group accounted for 67.96%(0.70±0.14 vs.1.03±0.14;t=-15.305,P<0.001)compared with the control group.The more severe the disease was,the smaller the SPA1 and SSI values were 64.27±12.12,55.22±12.23,43.75±12.33;0.78±0.14,0.71±0.11,0.61±0.09,and there were significant s

关 键 词：圆锥角膜 交联试剂 胶原 生物力学现象 角膜 弹性 

分 类 号：R779.6[医药卫生—眼科]