食欲素系统参与偏头痛发生的研究进展  

Research progress of the orexinergic system in migraine attack generation

作　　者：武守义 王蕾[1] 朱辰路 王永刚[2] Wu Shouyi;Wang Lei;Zhu Chenlu;Wang Yonggang(Department of Neurology,Lanzhou University Second Hospital,Lanzhou 730030,China;Department of Headache,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China)

机构地区：[1]兰州大学第二医院神经内科,兰州730030 [2]首都医科大学附属北京天坛医院头痛科,北京100070

出　　处：《中华神经科杂志》2022年第8期921-924,共4页Chinese Journal of Neurology

基　　金：国家自然科学基金(31770800,91849104)。

摘　　要：偏头痛是一种复杂的脑功能障碍,下丘脑被认为可能参与偏头痛的发生。下丘脑可以分泌多种神经肽,其中食欲素在能量代谢、睡眠觉醒、应激和疼痛中发挥重要作用,这些生理功能障碍与偏头痛的临床症状密切相关,因此未来下丘脑食欲素系统在偏头痛中的机制研究可能为临床治疗提供新的思路。文中探讨了下丘脑食欲素系统与偏头痛前驱症状的关系,同时对下丘脑食欲素系统在偏头痛中可能的作用及机制作一简要综述。Migraine is a complex disorder of brain function.The hypothalamus has been identified to play a crucial role in attack generation and secretes various neuropeptides.The orexinergic system plays a role in energy metabolism,arousal,sleep,stress and pain modulation.These disorders are closely related to clinical symptoms of migraine.Therefore,the study of the mechanism of hypothalamic orexinergic system in migraine may provide a new perspective for treatment.This article discusses the relationship between hypothalamic orexin system and migraine premonitory symptoms,and briefly summarizes the possible role and mechanism of hypothalamic orexin system in migraine.

关 键 词：下丘脑 偏头痛 食欲素 

分 类 号：R747.2[医药卫生—神经病学与精神病学]