外周血中间型单核细胞增多与弥漫大B细胞淋巴瘤疾病进展的相关性研究  

Correlation between Peripheral Blood Intermediate Monocytes In⁃creased and the Disease Progression of Patients with Diffuse Large B⁃Cell Lymphoma

作　　者：胡泉泉 王会平[2] 顾康生[3] 翟志敏[2] 李延莉 HU Quan-Quan;WANG Hui-Ping;GU Kang-Sheng;ZHAI Zhi-Min;LI Yan-Li(Department of Pathology,School of Basic Medical Sciences,Anhui Medical University,Hefei 230032,Anhui Province,China;Department of Hematology,The Second Affiliated Hospital of Anhui Medical University,Hefei 230601,Anhui Province,China;Department of Oncology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,Anhui Province,China;Department of Pathology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,Anhui Province,China)

机构地区：[1]安徽医科大学基础医学院病理解剖学教研室,安徽合肥230032 [2]安徽医科大学第二附属医院血液科,安徽合肥230601 [3]安徽医科大学第一附属医院肿瘤科,安徽合肥230022 [4]安徽医科大学第一附属医院病理科,安徽合肥230022

出　　处：《中国实验血液学杂志》2022年第4期1116-1122,共7页Journal of Experimental Hematology

基　　金：国家自然科学基金(81700194),国家自然科学基金(81670179)。

摘　　要：目的:探讨弥漫大B细胞淋巴瘤(DLBCL)患者外周血单核细胞亚群变化及临床意义。方法:采用流式细胞术检测82例DLBCL患者(包括32例初诊、29例缓解以及21例复发)和30例健康对照者外周血单核细胞亚群百分比,并分析其与DLBCL患者临床特征的相关性及其诊断价值。结果:与健康对照组相比,DLBCL初诊组患者中间型单核细胞亚群占总单核细胞比例明显升高(t=5.888,P<0.01)。DLBCL复发组患者中间型单核细胞亚群所占比例明显高于初诊组(t=2.106,P=0.04)和缓解组(t=6.882,P<0.01),并且初诊组患者中间型单核细胞亚群比例高于缓解组(t=3.969,P<0.01)。随着国际预后指数(IPI)评分的升高,DLBCL患者的中间型单核细胞亚型百分比增多(r=0.37)。当截点值为中间型单核细胞比例10.91%时,整体样本作为早期诊断指标的灵敏度和特异度分别为90.60%和91.00%。结论:DLBCL患者疾病进展与中间型单核细胞增多相关,可作为DLBCL潜在的诊断指标。Objective:To explore the distribution characteristics and clinical significance of peripheral blood monocyte subgroups in patients with diffuse large B⁃cell lymphoma(DLBCL).Methods:The percentage of peripheral blood monocyte subsets of 82 DLBCL patients(including 32 newly diagnosis,29 remission and 21 relapse)and 30 healthy controls were detected by flow cytometry,and the correlation with the clinical characteristics and its diagnostic value of DLBCL were analyzed.Results:The proportion of intermediate monocytes in patients with newly diagnosed DLBCL group was higher than that in healthy controls(t=5.888,P<0.01).The proportion in relapsed group was higher than those in newly diagnosed DLBCL group(t=2.106,P=0.04)and remission group(t=6.882,P<0.01),and the proportion of intermediate monocytes in newly diagnosed DLBCL group was higher than that in Remission group(t=3.969,P<0.01).With the increase of International Prognostic Index(IPI)score,the percentage of intermediate monocytes in patients with DLBCL increased(r=0.37).Furthermore,when the proportion of intermediate monocytes was 10.91%as the cut⁃off value,the sensitivity and specificity of the whole sample were 90.60%and 91.00%,respectively.Conclusion:The disease progression is related to the increased intermediate monocytes,which can be used as a potential diagnostic index for DLBCL.

关 键 词：弥漫大B细胞淋巴瘤 中间型单核细胞 流式细胞术 疾病进展 诊断指标 

分 类 号：R733.1[医药卫生—肿瘤]