神经胶质细胞在血管性认知障碍发病机制中的研究进展  

Research progress of glial cells in the pathogenesis of vascular cognitive impairment

作　　者：高昕 杜冰滢 陈晶晶[1] 毕晓莹[1] Gao Xin;Du Bingying;Chen Jingjing;Bi Xiaoying(Department of Neurology,The First Affiliated Hospital of Naval Medical University)

机构地区：[1]海军军医大学(第二军医大学)第一附属医院神经内科,上海200433

出　　处：《重庆医科大学学报》2022年第7期753-757,共5页Journal of Chongqing Medical University

基　　金：国家自然科学基金资助项目(编号:81871040)。

摘　　要：血管性认知障碍(vascular cognitive impairment,VCI)是由脑血管病变及相关危险因素引起的从轻度认知障碍到痴呆的一大类疾病。VCI的病理特征主要包括白质损伤、脱髓鞘与神经炎症。神经胶质细胞是大脑内数量最多的细胞,对于维持中枢神经系统正常功能具有重要作用。最近的研究发现神经胶质细胞在VCI的发病中扮演重要角色。探讨神经胶质细胞的作用有助于提高对VCI的认识,为疾病的防治提供新的思路。Vascular cognitive impairment(VCI)is a kind of disease caused by cerebrovascular diseases and other related risk factors,ranging from mild cognitive impairment to dementia.The pathological features of VCI mainly include white matter lesions,demyelination and neuroinflammation.Glial cells are the most numerous cells in the brain,and play an important role in maintaining the normal function of the central nervous system.Recent studies have found that glial cells play an important role in the pathogenesis of vascular cognitive impairment.Exploring the role of glial cells will help improve our understanding of VCI and provide new ideas for the prevention and treatment of the disease.

关 键 词：血管性认知障碍 神经炎症 白质损伤 小胶质细胞 星形胶质细胞 少突胶质细胞 少突胶质细胞前体细胞 

分 类 号：R743.9[医药卫生—神经病学与精神病学]