Basophils orchestrate kidney fibrosis  

作　　者：Camille Chauvin Jagadeesh Bayry 

机构地区：[1]Institut National de la Santéet de la Recherche Médicale,Centre de Recherche des Cordeliers,Sorbonne Université,Universitéde Paris,Paris,France [2]Department of Biological Sciences&Engineering,Indian Institute of Technology Palakkad,Palakkad,India

出　　处：《Cell Research》2022年第8期713-714,共2页细胞研究（英文版）

基　　金：Jagadeesh Bayry,email:[e-mail]。

摘　　要：Basophils,though representing a minor population of leukocytes,have diverse roles in various pathophysiologies.A recent report provides an additional evidence on the pathogenic role of basophils in promoting kidney fibrosis by secreting IL-6 and promoting the Th17 cell differentiation.Basophils are rare granulocytes that participate in T helper(Th)type 2 immunity,principally through the secretion of interleukins IL-4 and IL-13.Besides their role in the defense against helminth infections,basophils play a major role in the pathogenesis of various allergic inflammatory diseases,autoimmune diseases,and cancer.1 Basophils express a diverse array of receptors,and hence could sense signals from various sources including cytokines,tolllike receptor agonists,and allergens,and subsequently undergo rapid activation and release inflammatory mediators.In addition to IL-4 and IL-13,basophils produce histamine,prostaglandins,leukotrienes,IL-6 and chemokines in response to the stimuli.All these inflammatory mediators are potential contributors of basophil-mediated pathogenesis.

关 键 词：hence IMMUNITY diverse 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]