光动力联合干扰素序贯疗法治疗有生育要求女性宫颈低级别鳞状上皮内病变47例临床疗效  

Clinical efficacy of photodynamic combined with interferon sequential therapy in the treatment of 47 cases of cervical low-grade squamous intraepithelial lesions in women with fertility requirements

作　　者：孟艳飞 翟瑞芳[2] 张晋巧[3] MENG Yanfei;ZHAI Ruifang;ZHANG Jinqiao(First Clinical Medical College of Shanxi Medical University,Taiyuan,Shanxi 030000,China;aDepartment of Gynecology,The First Hospital of Shanxi Medical University,Taiyuan,Shanxi 030000,China;Dermatological Department,The First Hospital of Shanxi Medical University,Taiyuan,Shanxi 030000,China)

机构地区：[1]山西医科大学第一临床医学系,山西太原030000 [2]山西医科大学第一医院妇科,山西太原030000 [3]山西医科大学第一医院皮肤科,山西太原030000

出　　处：《安徽医药》2022年第9期1752-1755,共4页Anhui Medical and Pharmaceutical Journal

基　　金：山西省自然科学基金项目(201801D121224)。

摘　　要：目的探讨光动力联合干扰素序贯疗法治疗有生育要求女性宫颈低级别鳞状上皮内病变(LSIL)的临床疗效。方法收集2019年1月至2020年2月就诊山西医科大学第一医院门诊,经阴道镜下宫颈活组织检查病理组织学及免疫组织化学结果证实为LSIL合并高危型人乳头瘤病毒(HR-HPV)持续感染的病人共200例,采用随机数字表法分成四组,每组50例。最后实际参加治疗并完成随访的共182例,空白对照组(40例)、干扰素治疗组(46例)、光动力治疗组(49例)、光动力+干扰素序贯治疗组(47例)。比较四组病人一疗程结束后第3个月、6个月和9个月,宫颈HR-HPV的转阴率及LSIL的痊愈率。结果光动力+干扰素序贯治疗组治疗结束后第3个月、6个月和9个月宫颈HR-HPV的转阴率(72.3%、87.2%、93.6%)均高于光动力治疗组(42.9%、61.2%、71.4%)、干扰素治疗组(26.1%、39.1%、50.0%)和空白对照组(0%、2.5%、5.0%)(P<0.05)。光动力+干扰素序贯治疗组治疗结束后第3个月、6个月、9个月宫颈LSIL的痊愈率(78.7%、87.2%、95.7%)均高于光动力治疗组(59.2%、67.3%、79.6%)、干扰素治疗组(28.3%、39.1%、52.2%)和空白对照组(2.5%、12.5%、20.0%)(P<0.05)。结论光动力及干扰素治疗宫颈HR-HPV持续感染及LSIL的痊愈均有效,但两者联合效果更佳,同时又可以保留病人宫颈的完整性,为有生育要求的病人提供了满意的治疗方案。Objective To investigate the clinical efficacy of photodynamic combined with interferon sequential therapy in the treatment of cervical low grade squamous intraepithelial lesions(LSILs)in women with fertility requirements.Methods A total of 200 patients who were admitted to the First Hospital of Shanxi Medical University from January 2019 to February 2020 and confirmed to have LSIL combined with high-risk human papillomavirus(HR-HPV)by colposcopy cervical biopsy histopathology and immunohistochemistry.The patients were divided into four groups by the random number table method,with 50 patients in each group.Finally,a total of 182 cases actually participated in the treatment and completed the follow-up,including the blank control group(40 cases),the interferon treatment group(46 cases),the photodynamic therapy group(49 cases),and the photodynamic+interferon sequential treatment group(47 cases).The negative rate of cervical HR-HPV and the cure rate of LSIL were compared in the 3 rd,6 th and 9 th months after the first course of treatment in the four groups.Results The negative rate of cervical HR-HPV at 3 months,6 months and 9 months after treatment in the photodynamic+interferon sequential therapy group(72.3%,83.7%,93.6%)was higher than those in the photodynamic therapy group(42.9%,61.2%,71.4%),interferon treatment group(26.1%,39.1%,50.0%)and blank control group(0%,2.5%,5.0%)(P<0.05).The cure rates of cervical LSIL(78.7%,87.2%,95.7%)in the photodynamic+interferon sequential therapy group at the 3 rd,6 th and 9 th months after treatment were higher than those in the photodynamic treatment group(59.2%,67.3%,79.6%),interferon group(28.3%,39.1%,52.2%)and blank control group(2.5%,12.5%,20.0%)(P<0.05).Conclusion Both photodynamic and interferon therapy are effective in the treatment of persistent cervical HR-HPV infection and the recovery of LSIL,but the combined effect of the two is better,and the integrity of the patient’s cervix can be preserved,providing a satisfactory treatment plan for patients with fertility re

关 键 词：宫颈鳞状上皮内病变 高危型人乳头瘤病毒 光化学疗法 干扰素 保留生育能力 女性 

分 类 号：R737.33[医药卫生—肿瘤]