格林-巴利综合征患者疾病严重程度与抗甲状腺抗体水平的相关性分析  

Correlation analysis of disease severity and anti-thyroid antibody level in patients with Guillain-Barrésyndrome

作　　者：刘志伟 李怡萌 张海峰[1] 连亚军[1] 程璇[1] LIU Zhiwei;LI Yimeng;ZHANG Haifeng;LIAN Yajun;CHENG Xuan(Department of Neurology,the First Affiliated Hospital of Zhengzhou University,Henan Province,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院神经内科,河南郑州450052

出　　处：《中国医药导报》2022年第23期70-73,共4页China Medical Herald

基　　金：国家自然科学基金青年科学基金项目(81701295)。

摘　　要：目的分析格林-巴利综合征(GBS)患者疾病严重程度与抗甲状腺抗体及甲状腺激素的相关性。方法选取2013年10月至2021年3月郑州大学第一附属医院收治的163例GBS患者,根据高峰期休斯功能分级量表评分将其分为轻型组(50例)和重型组(113例)。收集患者的临床资料,分析疾病严重程度与抗甲状腺抗体及甲状腺激素的相关性及影响疾病严重程度的危险因素。结果重型组入院前病程短于轻型组,年龄、抗甲状腺过氧化物酶自身抗体(aTPOAb)、抗甲状腺球蛋白抗体(aTGAb)水平高于轻型组,差异有统计学意义(P<0.05)。GBS患者疾病严重程度与血清aTPOAb和aTGAb水平呈正相关(r=0.366、0.394,P<0.05),与甲状腺激素水平无相关性(P>0.05)。年龄、aTGAb水平是疾病严重程度的影响因素(OR>1,P<0.05)。结论年龄、aTGAb水平是GBS患者疾病严重程度的独立危险因素,年龄越高,aTGAb水平越高,GBS患者的病情往往越重。Objective To analyze the correlation of disease severity with antithyroid antibody and thyroid hormone in patients with Guillain-Barrésyndrome(GBS).Methods A total of 163 GBS patients admitted to the First Affiliated Hospital of Zhengzhou University from October 2013 to March 2021 were selected.They were classified as mild group(50 cases)and severe group(113 cases)according to the Hughes functional grading scale score.Clinical data of patients were collected,and the correlation between disease severity and antithyroid antibody and thyroid hormone,and the risk factors influencing disease severity were analyzed.Results The course of disease before admission in severe group was shorter than that in mild group,and age,the levels of anti-thyroid peroxidase autoantibody(aTPOAb),and anti-thyroid globulin antibody(aTGAb)were higher than those in mild group,and the differences were statistically significant(P<0.05).The disease severity of GBS patients was positively correlated with serum aTPOAb and aTGAb levels(r=0.366,0.394,P<0.05),but not with thyroid-stimulating hormone level(P>0.05).Age and aTGAb level were the influencing factors of disease severity(OR>1,P<0.05).Conclusion ATGAb is an independent risk factor for disease severity in GBS patients.The older the age,the higher the level of aTGAb,and the more severe the disease of GBS patients.

关 键 词：格林-巴利综合征 抗甲状腺抗体 年龄 疾病严重程度 

分 类 号：R744.5[医药卫生—神经病学与精神病学]