轻型地中海贫血孕妇孕早期铁蛋白水平、甲状腺功能及胰腺功能检测结果分析  

Analysis of the detection results of ferritin level,thyroid function,and pancreatic function in early pregnant women with minor thalassemia

作　　者：周晓萍[1] 邓雨萍 杨鑫 许颖[1] ZHOU Xiaoping;DENG Yuping;YANG Xin;XU Ying(Department of Laboratory Medicine,the First Affiliated Hospital of Chengdu Medical College,Sichuan Province,Chengdu 610500,China;School of Laboratory Medicine,Chengdu Medical College,Sichuan Province,Chengdu 610500,China)

机构地区：[1]成都医学院第一附属医院检验科,四川成都610500 [2]成都医学院检验医学院,四川成都610500

出　　处：《中国医药导报》2022年第23期93-96,共4页China Medical Herald

基　　金：四川省科技厅应用基础项目(2019YJ0589)。

摘　　要：目的探讨轻型地中海贫血孕妇孕早期铁蛋白(Fer)水平、甲状腺功能、胰腺功能的变化情况。方法选取2018年1月至2021年10月成都医学院第一附属医院进行产检的孕龄为3个月的轻型地中海贫血孕妇160例为地贫组,选取同期正常健康孕妇200名为对照组。检测两组促甲状腺激素(TSH)、游离三碘甲状腺激素(FT_(3))、游离甲状腺激素(FT_(4))、甲状腺球蛋白抗体(Tg-Ab),甲状腺过氧化物酶抗体(TPO-Ab)、Fer、血红蛋白(Hb)、空腹血糖(FPG)、空腹胰岛素(FINS)水平。结果两组TSH、FT_(3)、FT_(4)、Tg-Ab、TPO-Ab比较,差异无统计学意义(P>0.05)。两组甲状腺功能异常的患病率比较,差异无统计学意义(P>0.05)。两组FPG、FINS、胰岛素抵抗指数比较,差异无统计学意义(P>0.05)。地贫组Hb低于对照组,Fer高于对照组,差异有统计学意义(P<0.05)。结论轻型地中海贫血孕妇孕早期甲状腺功能、胰腺功能未发生显著性变化,但Fer、Hb水平会受到影响。Objective To investigate the changes of ferritin(Fer)level,thyroid function,and pancreatic function in pregnant women with minor thalassemia.Methods A total of 160 pregnant women with minor thalassemia at the gestational age of three months who underwent prenatal examinations in the First Affiliated Hospital of Chengdu Medical College from January 2018 to October 2021 were selected as the thalassemia group,and 200 healthy pregnant women in the same period were selected as the control group.The levels of thyroid stimulating hormone(TSH),free triiodothyronine(FT_(3)),free thyroid hormone(FT_(4)),thyroglobulin antibody(Tg-Ab),thyroperoxidase antibody(TPO-Ab),fasting plasma glucose(FPG),fasting plasma insulin(FINS),Fer,and hemoglobin(Hb)were measured between the two groups.Results There were no significant differences in TSH,FT_(3),FT_(4),Tg-Ab,and TPO-Ab between the two groups(P>0.05).There was no significant difference in the prevalence of thyroid dysfunction between the two groups(P>0.05).There were no significant differences in FPG,FINS,and the homeostasis model assessment of insulin resistance between the two groups(P>0.05).Hb in the thalassemia group was lower than that in the control group,Fer was higher than that in the control group,and the differences were statistically significant(P<0.05).Conclusion Thyroid function and pancreas function of pregnant women with mild thalassemia do not change significantly in early pregnancy,but Fer and Hb levels are affected.

关 键 词：地中海贫血孕妇 甲状腺激素 铁蛋白 胰岛素抵抗 

分 类 号：R394.5[医药卫生—医学遗传学]