BIM基因多态性与HBV相关性肝癌预后的关系  

Association between BIM gene polymorphisms and prognosis of patients with HBV-related liver cancer

作　　者：张洪宇[1] 王伟[2] 张咏梅 张波[3] 闫蕾 ZHANG Hong-yu;WANG Wei;ZHANG Yong-mei;ZHANG Bo;YAN Lei(People's Hospital of Ningria Hui Autonomous Region(The First Affiliated Hospital of Northwest University for Nationalities),Yinchuan,Ningria 750002,China;不详)

机构地区：[1]宁夏回族自治区人民医院(西北民族大学第一附属医院)介入与血管外科,宁夏银川750002 [2]宁夏回族自治区人民医院(西北民族大学第一附属医院)感染疾病科,宁夏银川750002 [3]浙江大学医学院附属第二医院肝胆外科,浙江杭州310009

出　　处：《中华医院感染学杂志》2022年第1期26-30,共5页Chinese Journal of Nosocomiology

基　　金：宁夏回族自治区自然科学基金资助项目(2019AAC03171)。

摘　　要：目的 探究BIM基因多态性与乙型肝炎病毒(HBV)相关性肝癌患者生存预后的关系。方法 选取2017年3月-2020年3月宁夏回族自治区人民医院与浙江大学医学院附属第二医院收治的90例HBV相关性肝癌患者、103例HBV相关性肝炎患者以及同期体检的90名健康者为肝癌组、肝炎组以及对照组,检测各组BIM基因多态性,分析其在肝癌病情发生、进展以及预后中的作用。结果 肝癌组、肝炎组以及对照组BIM基因rs761706位点和rs724710位点基因型分布比较差异有统计学意义(P<0.05);rs761706位点多态性与肝癌患者饮酒史、肿瘤家族史、吸烟史有关(P<0.05),rs724710位点多态性与肝癌患者饮酒史、肿瘤个数、门静脉癌栓有关(P<0.05);肝癌BIM基因rs761706位点CC基因型患者生存率高于TC+TT基因型患者(P<0.05),rs724710位点CC基因型患者生存率低于CT+TT基因型患者(P<0.05);饮酒史、rs724710位点是肝癌患者预后影响因素(P<0.05)。结论 BIM基因rs724710位点多态性与HBV相关性肝癌疾病发生、进展以及预后相关,可以考虑将其作为患者病情诊断、预后评估辅助工具。OBJECTIVE To explore the relationship between BIM gene polymorphisms and prognosis of the patients with hepatitis B virus(HBV)-related liver cancer. METHODS From Mar 2017 to Mar 2020, totally 90 patients with HBV-related liver cancer and 103 patients with HBV-related hepatitis who were treated in People′s Hospital of Ningxia Hui Autonomous Region and the Second Affiliated Hospital of Medical College of Zhejiang University were enrolled in the study and were respectively assigned as the liver cancer group and the hepatitis group, meanwhile, 90 healthy people who received physical examination were chosen as the control group. The BIM gene polymorphisms were detected, and the effects on occurrence, progression and prognosis of liver cancer were observed. RESULTS There was significant difference in the distribution of genotypes at rs761706 and rs 724710 loci of BIM gene among the liver cancer group, the hepatitis group and the control group(P<0.05). The polymorphism at rs761706 locus was associated with drinking history, family history of tumors and smoking history of the liver cancer patients(P<0.05), the polymorphism at rs724710 locus was associated with drinking history, number of tumors and portal vein tumor thrombus of the liver concer patients(P<0.05). The survival rate of the patients with CC genotype at rs761706 locus of BIM gene was significantly higher than that of the patients with TC plus TT genotype(P<0.05), the survival rate of the patients with CC genotype at rs724710 locus was significantly lower than that of the patients with CT plus TT genotype(P<0.05). The drinking history and rs724710 locus were the influencing factors for the prognosis of the liver cancer patients(P<0.05). CONCLUSION The polymorphisms at rs724710 loci of BIM gene are associated with the occurrence, progression and prognosis of the patients with HBV-related liver cancer, which can be taken as auxiliary means for diagnosis of illness condition and assessment of prognosis.

关 键 词：BIM基因多态性 乙型肝炎病毒 肝癌 生存预后 

分 类 号：R735.7[医药卫生—肿瘤]