聚丙交酯-乙交酯的合成及表征的研究进展  

Research Progress of Synthesis and Characterization of Poly(lactide-co-glycolide)

作　　者：顾伟楠 田阳 赵子明 张慧 郑爱萍 GU Weinan;TIAN Yang;ZHAO Ziming;ZHANG Hui;ZHENG Aiping(School of Pharmacy,Xuzhou Medical University,Xuzhou 221004;State Key Lab.of Toxicology and Medical Countermeasures,Beijing Institute of Pharmacology and Toxicology,Academy of Military Sciences,Beijing 100850)

机构地区：[1]徐州医科大学药学院,江苏徐州221004 [2]军事科学院军事医学研究院毒物药物研究所,抗毒药物与毒理学国家重点实验室,北京100850

出　　处：《中国医药工业杂志》2022年第6期819-832,共14页Chinese Journal of Pharmaceuticals

基　　金：国家自然科学基金项目(81573357)。

摘　　要：聚丙交酯-乙交酯(PLGA)具有良好的缓释性能及生物相容性,是一类应用广泛的可生物降解的高附加值医用药用材料。PLGA的常规质量标准评价体系仅包括谱图比对和一般性检查等,不能很好地区分不同型号PLGA之间的差异。本研究从PLGA的合成入手,阐述了国内外关于PLGA表征方法的研究进展,以期为PLGA的表征、制备及其在国内高端制剂中的广泛应用提供文献支持。Poly(lactide-co-glycolide)(PLGA) is a widely used biodegradable medical and pharmaceutical material with high added value because of its excellent sustained-release performance and biocompatibility.The conventional quality standard evaluation system of PLGA only involves spectrum comparison and general inspection,which cannot distinguish the differences between different types of PLGA well.Starting with the synthesis of PLGA,this paper summarizes the research progress in characterization methods of PLGA worldwide,and looks forward to providing literature support for the characterization,preparation and application of PLGA in domestic high-end preparations.

关 键 词：聚丙交酯-乙交酯 合成 表征 药用辅料 高端制剂 

分 类 号：R943[医药卫生—药剂学]