纳米银-二氧化钛填充树脂力学及光控抗菌性能研究  

Mechanical and light-activated antibacterial properties of resin filled with Ag-TiO_(2) nanoparticles

作　　者：潘世奇 鲁舒心 李若玉 张翔宇[1] 陈维毅 PAN Shiqi;LU Shuxin;LI Ruoyu;ZHANG Xiangyu;CHEN Weiyi(Shanxi Key Laboratory of Biomedical Metal Materials,Collge of Materials Science and Engineering,Taiyuan University of Technology,Taiyuan 030024,P.R.China;College of Biomedical Engineering,Taiyuan University of Technology,Taiyuan 030024,P.R.China)

机构地区：[1]太原理工大学材料科学与工程学院医用金属山西省重点实验室,太原030024 [2]太原理工大学生物医学工程学院,太原030024

出　　处：《生物医学工程学杂志》2022年第4期749-758,共10页Journal of Biomedical Engineering

基　　金：国家自然科学基金(52171240);中国博士后基金(2021M691992)。

摘　　要：力学性能差和易引起细菌感染是牙科修复树脂在临床使用中所面临的主要问题。基于此,本研究通过合成具有良好光催化性能的银—二氧化钛(Ag-TiO_(2))纳米颗粒,并将其添加到复合树脂中,以期改善树脂的力学性能及光催化抗菌能力。首先,本文对Ag-TiO_(2)纳米颗粒及复合树脂的微观结构和化学成分进行表征。结果表明,Ag以单质和氧化态两种形式存在于Ag-TiO_(2)中,而Ag-TiO_(2)纳米颗粒又均匀分散在复合树脂中。本文进一步的力学实验结果显示,Ag-TiO_(2)的填充显著提高了复合树脂的力学性能。而抗菌实验结果表明,在660 nm可见光照射下,由于光催化作用,Ag-TiO_(2)纳米颗粒填充复合树脂10 min即可显示出优良的抗菌能力;而在无光照条件下,随着Ag离子的释放,Ag-TiO_(2)纳米颗粒填充复合树脂24 h后也可展现优良抗菌性能。综上所述,本研究为牙科复合树脂领域提供了抗菌新思路。The poor mechanical property and vulnerability to bacterial infections are the main problems in clinic for dental restoration resins.Based on this problem,the purpose of this study is to synthesize silver-titanium dioxide(AgTiO_(2))nanoparticles with good photocatalytic properties,and add them to the composite resin to improve the mechanical properties and photocatalytic antibacterial capability of the resin.The microstructure and chemical composition of AgTiO_(2) nanoparticles and composite resins were characterized.The results indicated that Ag existed in both metallic and silver oxide state in the Ag-TiO_(2),and Ag-TiO_(2) nanoparticles were uniformly dispersed in the resins.The results of mechanical experiments suggested that the mechanical properties of the composite resin were significantly improved due to the incorporation of Ag-TiO_(2) nanoparticles.The antibacterial results indicated that the Ag-TiO_(2) nanoparticle-filled composite resins exhibited excellent antibacterial activities under 660 nm light irradiation for 10 min due to the photocatalysis,and the Ag-TiO_(2) nanoparticle-filled composite resins could also exhibit excellent antibacterial activities after contact with bacteria for 24 h without light irradiation because of the release of Ag ions.In summary,this study provides a new antibacterial idea for the field of dental composite resins.

关 键 词：复合树脂 力学性能 光控抗菌 生物相容性 

分 类 号：R783.1[医药卫生—口腔医学]