GOLPH3及PI3K在卵巢癌组织中的表达及意义  

Expression and significance of GOLPH3 and PI3K in ovarian cancer

作　　者：沈艳丽[1] 冯文广[1] 易金玲[1] SHEN Yanli;FENG Wenguang;YI Jinling(Department of Gynecology,the Fifth Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang,China,830000)

机构地区：[1]新疆医科大学第五附属医院妇科,新疆维吾尔自治区乌鲁木齐830000

出　　处：《分子诊断与治疗杂志》2022年第8期1342-1345,共4页Journal of Molecular Diagnostics and Therapy

基　　金：新疆维吾尔自治区自然科学基金(2018D01C309)。

摘　　要：目的探讨高尔基磷酸化蛋白3(GOLPH3)及3羧基磷脂酰肌醇激酶(PI3K)在卵巢癌组织中的表达及意义。方法选取2019年1月至2021年3月于新疆医科大学第五附属医院保存的卵巢癌组织标本87份,同时选取正常卵巢组织50份,采用免疫组化染色法检测GOLPH3及PI3K表达,分析不同组织GOLPH3及PI3K表达,以及与卵巢癌临床病理特征的关系,采用Spearman秩相关分析GOLPH3和PI3K相关性。结果卵巢癌组织GOLPH3及PI3K阳性表达率分别为75.86%和66.67%,明显高于正常卵巢组织的4.00%和8.00%,差异均有统计学意义(P>0.05)。浆液性、FIGO分期Ⅲ~Ⅳ期、中低分化、有淋巴结转移卵巢癌组织GOLPH3阳性表达率分别为84.38%、94.74%、88.33%和90.91%,明显高于非浆液性、Ⅰ~Ⅱ期、高分化、无淋巴结转移卵巢组织的52.17%、61.22%、48.15%和60.47%,差异均有统计学意义(P<0.05)。FIGO分期Ⅲ~Ⅳ期、中低分化、有淋巴结转移卵巢癌组织PI3K阳性表达率分别为84.21%、78.33%和84.09%,明显高于Ⅰ~Ⅱ期、高分化、无淋巴结转移卵巢组织的53.06%、40.74%和48.84%,差异均有统计学意义(P<0.05)。卵巢癌组织GOLPH3及PI3K表达呈正相关(rs=0.456,P<0.05)。GOLPH3阳性表达患者无进展生存时间为18个月,明显短于GOLPH阴性患者的29个月,差异有统计学意义(P<0.05);PI3K阳性表达患者无进展生存时间为13个月,明显短于PI3K阴性患者的26个月,差异有统计学意义(P<0.05)。结论卵巢癌组织中GOLPH3及PI3K表达在疾病发生发展中有重要作用,两者间存在一定相关性。Objective To investigate the expression and significance of Golgi phosphorylated protein 3(GOLPH3)and 3-carboxyphosphatidylinositol kinase(PI3K)in ovarian cancer.Methods The expression of GOLPH3 and PI3K in 87 specimens of ovarian cancer preserved in the Fifth Affiliated Hospital of Xinjiang Medical University from January 2019 to March 2021 and 50 normal ovarian tissues were detected by immunohistochemical staining.Spearman rank correlation was used to analyze the correlation between GOLPH3 and PI3K.Results The positive rates of GOLPH3 and PI3K in ovarian cancer tissues were 75.86% and 66.67%,respectively,which were significantly higher than those in normal ovarian tissues 4.00% and 8.00%(P>0.05).The positive rates of GOLPH3 in serous,FIGO stage Ⅲ~Ⅳ,moderately and poorly differentiated and lymph node metastasis ovarian cancer tissues were 84.38%,94.74%,88.33% and 90.91%,respectively,which were significantly higher than those in non-serous,stage Ⅰ~Ⅱ,highly differentiated and lymph node-free ovarian cancer tissues 84.38%,94.74%,88.33% and 90.91%(P<0.05).The positive expression rates of PI3K were 84.21%,78.33% and 84.09% in FIGO stage Ⅲ~Ⅳ,moderately and poorly differentiated ovarian cancer and ovarian cancer with lymph node metastasis,which were significantly higher than those in stage Ⅰ~Ⅱ,highly differentiated and non-lymph node metastasis ovarian cancer 53.06%,40.74% and 48.84%(P<0.05).The expression of GOLPH3 and PI3K in ovarian cancer was positively correlated(rs=0.456,P<0.05).The progression free survival time of patients with positive expression of GOLPH3 was 18 months,which was significantly shorter than 29 months of patients with negative expression of GOLPH3(P<0.05).The progression free survival time of PI3K positive patients was 13 months,which was significantly shorter than that of PI3K negative patients(26 months)(P<0.05).Conclusion The expression of GOLPH3 and PI3K in ovarian cancer plays an important role in the occurrence and development of the disease,and there is a certain correlati

关 键 词：高尔基磷酸化蛋白3 3羧基磷脂酰肌醇激酶 卵巢癌 

分 类 号：R737.31[医药卫生—肿瘤]