精神分裂症患者血清VILIP-1、SOD-1表达及临床意义  

Expression and clinical significance of serum VILIP-1 and SOD-1 in patients with schizophrenia

作　　者：马淑君[1] 林育波 吴映娥[2] 纪晓斌 郑闻华 MA Shujun;LIN Yubo;WU Yinge;JI Xiaobin;ZHENG Wenhua(Department of Psychiatry,the Fourth People's Hospital of Shantou,Shantou,Guangdong,China,515041;Department of Laboratory Medicine,the First Affiliated Hospital of Shantou University,Guangdong,China,515041)

机构地区：[1]汕头市第四人民医院精神科,广东汕头515041 [2]汕头大学附属第一医院检验科,广东汕头515041

出　　处：《分子诊断与治疗杂志》2022年第8期1375-1378,1384,共5页Journal of Molecular Diagnostics and Therapy

基　　金：汕头市科技计划医疗卫生类别项目(191030115264208)。

摘　　要：目的探究精神分裂症患者血清视锥蛋白样蛋白-1(VILIP-1)、超氧化物歧化酶1(SOD-1)表达并探究其临床意义。方法选取在本院确诊的65例精神分裂症患者(疾病组)及同期在本院体检的65例健康者(健康组)作为研究对象。以酶联免疫吸附法检测血清VILIP-1、SOD-1、降钙素原(PCT)水平,以Pearson法分析精神分裂症患者血清VILIP-1、SOD-1水平表达与PCT水平的关系及两者间的相关性。再以ROC曲线下面积评估VILIP-1、SOD-1诊断精神分裂症的价值,以多因素Logistic回归分析影响精神分裂症发生的危险因素。结果疾病组血清VILIP-1、SOD-1、PCT水平高于健康组,差异有统计学意义(P<0.05)。血清VILIP-1、SOD-1、PCT表达与BPRS总分、敌对性、激活性、思维障碍、缺乏活力、焦虑抑郁各项评分均呈正相关(P<0.05)。精神分裂症患者血清VILIP-1、SOD-1表达水平与PCT均呈正相关(r=0.643,0.557,P<0.05)。血清VILIP-1、SOD-1水平的ROC曲线下面积分别为0.773、0.712,VILIP-1的特异度优于SOD-1,SOD-1的敏感度优于VILIP-1。两者联合检测ROC曲线下面积为0.911,特异度均优于单独检测。VILIP-1>586.51 pg/mL、SOD-1>6.25μg/L为影响精神分裂症发生的独立危险因素(P<0.05)。结论精神分裂症患者血清VILIP-1、SOD-1水平呈高表达,两者与炎症反应均呈正相关,可能参与疾病进展,为影响精神分裂症发生的独立危险因素,可能为诊断精神分裂症的潜在指标。Objective To explore the expression of serum visinin-like protein-1(VILIP-1)and superoxide dismutase-1(SOD-1)in patients with schizophrenia and explore their clinical significance.Methods Sixty-five patients with schizophrenia(disease group)diagnosed in this hospital and 65 healthy people(healthy group)who received physical examination in this hospital during the same period were selected as the research objects.Enzyme-linked immunosorbent assay was used to detect levels of serum VILIP-1,SOD-1,and procalcitonin(PCT),Pearson method was used to analyze the relationship between serum levels of VIILIP-1,SOD-1 and PCT levels in patients with schizophrenia and the correlation between the two.The area under the ROC curve was used to evaluate the value of VILIP-1 and SOD-1 in diagnosing schizophrenia,multivariate Logistic regression was used to analyze the risk factors that affected the occurrence of schizophrenia.Results The serum levels of VILIP-1,SOD-1 and PCT in the disease group were higher than those in the healthy group,and the difference was statistically significant(P<0.05).Serum VILIP-1,SOD-1,and PCT expressions were positively correlated with BPRS total score,hostility,activation,thinking disorder,lack of energy,anxiety,and depression scores(P<0.05).The expression levels of serum VILIP-1 and SOD-1 in patients with schizophrenia were positively correlated with PCT(r=0.643,0.557,P<0.05).The areas under the ROC curve of serum VILIP-1 and SOD-1 levels were 0.773 and 0.712,respectively.The specificity of VILIP-1 was better than that of SOD-1,and the sensitivity of SOD-1 was better than that of VILIP-1.The area under the ROC curve of the combined detection of the two was 0.911,and the specificity was better than that of the single detection.VILIP-1>586.51 pg/m L and SOD-1>6.25μg/L were independent risk factors for schizophrenia(P<0.05).Conclusion The serum levels of VILIP-1 and SOD-1 are highly expressed in patients with schizophrenia,and both of which are positively correlated with inflammation.They may be involve

关 键 词：精神分裂症 超氧化物歧化酶1 视锥蛋白样蛋白-1 临床意义 

分 类 号：R749.3[医药卫生—神经病学与精神病学]