低频与高频重复经颅磁刺激治疗帕金森病患者的临床效果对比  

Comparison of Clinical Effects of Low Frequency and High Frequency Repetitive Transcranial Magnetic Stimulation in the Treatment of Patients with Parkinson Disease

作　　者：苏清平 黄炼红[1] 徐维[1] 葛舒颖[1] 陈可爱[1] 陈恩玉[1] 游娜 李玲[1] 上官豪 陈剑豪 SU Qingping;HUANG Lianhong;XU Wei;GE Shuying;CHEN Ke’ai;CHEN Enyu;YOU Na;LI Ling;SHANGGUAN Hao;CHEN Jianhao(不详;Fujian Provincial Hospital,Fuzhou 350001,China)

机构地区：[1]福建省立医院,福建福州350001

出　　处：《中外医学研究》2022年第22期14-17,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：福建医科大学启航基金项目(2019QH1162)。

摘　　要：目的:对比低频与高频重复经颅磁刺激治疗帕金森病患者的临床效果。方法:将2018年6月-2021年6月于福建省立医院就诊的100例帕金森病患者,按照随机数字表法将患者分为对照组(n=50)和研究组(n=50)。对照组采取低频重复经颅磁刺激治疗,研究组采取高频重复经颅磁刺激治疗。比较两组治疗前后帕金森病量表(UPDRSⅢ)、疲劳严重程度量表(FSS)、Epworth嗜睡量表(ESS)、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评分、非运动症状(静息运动阈值)、运动症状(10 m折返运动用时)及不良反应发生情况。结果:治疗前,两组UPDRSⅢ、FSS、ESS、HAMA、HAMD评分及静息运动阈值、10 m折返运动用时相比,差异均无统计学意义(P>0.05)。治疗后,两组UPDRSⅢ、FSS、ESS、HAMA、HAMD评分均低于治疗前,且研究组均低于对照组(P<0.05);治疗后,两组静息运动阈值较治疗前均降低,10 m折返运动用时较治疗前均缩短,且研究组均优于对照组(P<0.05);研究组不良反应发生率为8.00%,与对照组的10.00%相比,差异无统计学意义(P>0.05)。结论:将低频与高频重复经颅磁刺激分别应用于帕金森病患者治疗中,高频重复经颅磁刺激治疗更能改善帕金森病临床症状,缓解疲劳、嗜睡症状,减缓焦虑、抑郁情绪,改善非运动症状及运动症状,且安全可靠。Objective:To compare the clinical effects of low-frequency and high-frequency repetitive transcranial magnetic stimulation in the treatment of Parkinson disease.Method:A total of 100 patients with Parkinson disease(PD)treated in Fujian Provincial Hospital from June 2018 to June 2021 were divided into the control group(n=50)and the study group(n=50)by random number table method.The control group was treated with low-frequency repetitive transcranial magnetic stimulation,and the study group was treated with high-frequency repetitive transcranial magnetic stimulation.The scores of Parkinson disease scale(UPDRSⅢ),fatigue severity scale(FSS),Epworth sleepiness scale(ESS),Hamilton anxiety scale(HAMA),Hamilton depression scale(HAMD),non motor symptoms(resting motor threshold),motor symptoms(10 m reentry exercise time)before and after treatment,and adverse reactions were compared between two groups.Result:Before treatment,there were no significant differences in UPDRSⅢ,FSS,ESS,HAMA,HAMD scores,resting exercise threshold and 10 m reentry exercise time between two groups(P>0.05).After treatment,the UPDRSⅢ,FSS,ESS,HAMA and HAMD scores in two groups were lower than those before treatment,and the indexes in the study group were lower than those in the control group(P<0.05);after treatment,the resting exercise threshold of two groups were lower than those before treatment,and the times of 10 m reentry exercise were shorter than those before treatment,and the indexes in the study group were better than those of the control group(P<0.05).The incidence of adverse reactions in the study group was 8.00%,and there was no significant difference compared with 10.00%in the control group(P>0.05).Conclusion:Low frequency and high frequency repetitive transcranial magnetic stimulation are respectively applied to the treatment of patients with PD,high frequency repetitive transcranial magnetic stimulation can better improve the clinical symptoms of Parkinson disease,alleviate the symptoms of fatigue and sleepiness,alleviate anxiety a

关 键 词：帕金森病 低频 高频 重复经颅磁刺激 汉密尔顿焦虑量表 汉密尔顿抑郁量表 

分 类 号：R742.5[医药卫生—神经病学与精神病学]