Sema3A对口腔间充质干细胞功能的调控  

Regulation of Sema3A on oral mesenchymal stem cell function

作　　者：邢国奕 孙乐刚[1,2] 马向瑞 王文龙 Xing Guoyi;Sun Legang;Ma Xiangrui;Wang Wenlong(Department of Oral and Maxillofacial Surgery,Affiliated Hospital of Binzhou Medical College,Binzhou 256600,Shandong Province,China;School of Stomatology,Binzhou Medical College,Yantai 264003,Shandong Province,China)

机构地区：[1]滨州医学院附属医院口腔颌面外科,山东省滨州市256600 [2]滨州医学院口腔医学院,山东省烟台市264003

出　　处：《中国组织工程研究》2023年第10期1626-1633,共8页Chinese Journal of Tissue Engineering Research

基　　金：山东省自然科学基金博士基金(ZR2018BH026),项目负责人:马向瑞;山东省自然科学基金(ZR2019PH075),项目负责人:王文龙;山东省医药卫生科技发展计划面上项目(2017WS231),项目负责人:马向瑞。

摘　　要：背景:有研究发现,Sema3A不仅可以参与肿瘤生长、血管生成、骨重建、免疫调节以及其他生物和病理过程,此外,还有效促进口腔组织来源的间充质干细胞增殖及分化。因此,Sema3A可能为治疗口腔疾病造成的软硬组织损伤提供新思路和潜在新靶点。目的:文章将归纳Sema3A的多种生物学功能,重点以Sema3A调控口腔组织来源间充质干细胞增殖、分化、炎症环境的作用以及相关信号通路的研究进展作一综述,为Sema3A治疗口腔疾病及修复口腔软硬组织缺损提供可行性方案。方法:检索中国知网与Pub Med数据库1993年1月至2022年3月收录的与Sema3A和口腔间充质干细胞有关的文献,共纳入文献70篇进行综述分析。结果与结论:(1)Sema3A在组织工程领域有着极大的潜能,并且是多种疾病的潜在治疗因子。(2)目前Sema3A对口腔组织来源的间充质干细胞的相关研究文献相对较少,但基本确定Sema3A能够在口腔组织来源的间充质干细胞调控方面发挥积极作用。(3)炎症环境对干细胞的增殖分化有明显的抑制作用,但研究发现Sema3A可以在炎症环境下有效调控多种口腔间充质干细胞增殖分化,从而在炎症疾病中发挥重要作用。(4)基于Sema3A自身具有骨保护的生物功能,并且Sema3A可以有效增强口腔组织来源间充质干细胞的干细胞特性并诱导其增殖分化,其在调控口腔组织来源间充质干细胞分化成骨从而治疗骨组织缺损方面具有独特的优势。(5)研究Sema3A调控口腔组织来源间充质干细胞增殖分化,可以成为治疗口腔疾病的新思路,并在口腔内软硬组织修复和再生领域作出突破。BACKGROUND:Studies have found that Sema3 A can not only participate in tumor growth,angiogenesis,bone remodeling,immune regulation,and other biological and pathological processes,but also effectively promote the proliferation and differentiation of oral tissue-derived mesenchymal stem cells.Therefore,Sema3 A may provide new ideas and potential new targets for the treatment of soft and hard tissue damage caused by oral diseases.OBJECTIVE:To summarize the various biological functions of Sema3 A,focusing on the role of Sema3 A in regulating the proliferation,differentiation,and inflammatory environment of oral tissue-derived mesenchymal stem cells and the research progress of related signaling pathways so as to provide a feasible solution for Sema3 A to treat oral diseases and repair oral soft and hard tissue defects.METHODS:Articles related to Sema3 A and oral mesenchymal stem cells included in CNKI and Pub Med databases from January 1993 to March 2022 were searched.A total of 70 articles were included for review.RESULTS AND CONCLUSION:(1) Sema3 A has a great potential in the field of tissue engineering and is a potential therapeutic factor for various diseases.(2) At present,there are relatively few studies on Sema3 A on oral tissue-derived mesenchymal stem cells,but it is basically confirmed that Sema3 A can play an active role in the regulation of oral tissue-derived mesenchymal stem cells.(3) The inflammatory environment has a significant inhibitory effect on the proliferation and differentiation of stem cells,but studies have found that Sema3 A can effectively regulate the proliferation and differentiation of a variety of oral mesenchymal stem cells in an inflammatory environment,thus playing an important role in inflammatory diseases.(4) Because Sema3 A itself has the biological function of bone protection and Sema3 A can effectively enhance the stem cell characteristics of oral tissue-derived mesenchymal stem cells and induce their proliferation and differentiation,it has unique advantages on regulating the

关 键 词：SEMA3A 骨改建 轴突 肿瘤 口腔间充质干细胞 免疫 增殖 分化 

分 类 号：R459.9[医药卫生—治疗学] R363[医药卫生—临床医学] R364