partly National Key R&D Program of China(2023YFA1801200,2023YFA1801202);Major Program of the National Natural Science Foundation of China(T2394532);National Natural Science Foundation of China(82072489);The Foundation of Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions(NYKFKT2019007);Shenzhen Medical Research Fund(B2302011);The Sanming Project of Medicine in Shenzhen(SZZYSM202311013);The China Postdoctoral Science Foundational,2023M743679;Shenzhen Science and Technology Research Funding(JCYJ20220818101414032);Key Research Project of Science&Technology Department of Sichuan Province,China(2024YFFK0041)。
Osteoarthritis(OA)is a degenerative joint disease accompanied with the loss of cartilage and consequent nociceptive symptoms.Normal articular cartilage maintains at aneural state.Neuron guidance factor Semaphorin 3A(S...
supported in part by National Natural Science Foundation of China(32271364 & 31971240);Interdisciplinary innovation project from West China Hospital of Stomatology, Sichuan University(RD-03-202305)。
Bone formation and deposition are initiated by sensory nerve infiltration in adaptive bone remodeling. Here, we focused on the role of Semaphorin 3A(Sema3A), expressed by sensory nerves, in mechanical loads-induced bo...