增生型糖尿病性视网膜病变患者房水TNC、Sema3A、MCP-1与术后新生血管性青光眼的关系分析  

Analysis of the Relationship between Aqueous Humor TNC,Sema3A,MCP-1 and Postoperative Neovascular Glaucoma in Patients with Proliferative Diabetic Retinopathy

作　　者：汤翠翠 陈京霞 彭亮红 李征亚 陈刚 吴任萍 TANG Cui-cui;CHEN Jing-xia;PENG Liang-hong;LI Zheng-ya;CHEN Gang;WU Ren-ping(Department of Ophthalmology,General Hospital of the Southern Theatre Command of Chinese People's Liberation Army,Guangzhou,Guangdong,510010,China)

机构地区：[1]中国人民解放军南部战区总医院眼科,广东广州510010

出　　处：《现代生物医学进展》2024年第23期4574-4577,共4页Progress in Modern Biomedicine

基　　金：广东省医学科学技术研究基金项目(20221118203122660);广州市科技计划(2024A03J0694)。

摘　　要：目的:分析增生型糖尿病性视网膜病变(PDR)患者房水腱生蛋白C(TNC)、信号素3A(Sema3A)、单核细胞趋化蛋白-1(MCP-1)与术后新生血管性青光眼(NVG)的关系。方法:选取240例(300眼)PDR患者,均行玻璃体切割术治疗。患者术后随访1年,根据是否发生NVG将其分为并发NVG组与非并发NVG组。检测房水TNC、Sema3A、MCP-1水平,采用多因素logistic回归分析PDR患者术后NVG的影响因素。结果:240例(300眼)PDR患者术后1年发生NVG共55例(79眼),占比26.33%。并发NVG组房水TNC、Sema3A、MCP-1水平高于非并发NVG组(P<0.05)。视网膜无灌注区残留,同侧颈动脉狭窄>25%,TNC、Sema3A、MCP-1水平升高是PDR患者术后NVG发生的独立危险因素(P<0.05)。结论:房水TNC、Sema3A、MCP-1高表达为PDR患者术后NVG发生的独立危险因素。Objective:To analyze the relationship between aqueous humor tenascin C(TNC),semaphorins 3A(Sema3A),monocyte chemoattractant protein-1(MCP-1)and postoperative neovascular glaucoma(NVG)in patients with proliferative diabetic retinopathy(PDR).Methods:240(300 eyes)patients with PDR were selected,all patients underwent vitrectomy.Patients were followed up for 1 year after operation,and they were divided into concurrent NVG group and non-concurrent NVG group according to whether NVG occurred or not.The levels of TNC,Sema3A and MCP-1 in aqueous humor were detected,the influencing factors of postoperative NVG in PDR patients were analyzed by multivariate logistic regression.Results:240(300 eyes)of PDR patients had NVG in 55 cases(79 eyes)at 1 year after operation,accounting for 26.33%.The levels of aqueous humor TNC,Sema3A and MCP-1 in concurrent NVG group were higher than those in non-concurrent NVG group(P<0.05).Residual retinal perfusion zone,ipsilateral carotid artery stenosis>25%,and elevated TNC,Sema3A,and MCP-1 levels were independent risk factors for postoperative NVG in patients with PDR(P<0.05).Conclusion:The high expression of TNC,Sema3A and MCP-1 in aqueous humor are independent risk factor for postoperative NVG in PDR patients.

关 键 词：增生型糖尿病性视网膜病变 腱生蛋白C 信号素3A 单核细胞趋化蛋白-1 新生血管性青光眼 

分 类 号：R774[医药卫生—眼科]