房水Sema3A、Klotho、SDF-1与增生型糖尿病视网膜病变患者术后新生血管性青光眼的关系研究  

Study on the Relationship between Aqueous Humor Sema3A, Klotho,SDF-1 and Postoperative Neovascular Glaucoma in Patients with Proliferative Diabetic Retinopathy

作　　者：曾春梅[1] 邓斌[1] 白莹 李颖媛[1] 梁光丽[1] ZENG Chun-mei;DENG Bin;BAI Ying;LI Ying-yuan;LIANG Guang-li(Department of Ophthalmology,Chengdu Sixth People's Hospital,Chengdu,Sichuan,610051,China)

机构地区：[1]成都市第六人民医院眼科,四川成都610051

出　　处：《现代生物医学进展》2024年第12期2356-2360,共5页Progress in Modern Biomedicine

基　　金：四川省卫生厅科研基金项目(1931392)。

摘　　要：目的:探讨房水信号素3A(Sema3A)、克洛索(Klotho)、基质细胞衍生因子-1(SDF-1)与增生型糖尿病视网膜病变(PDR)患者术后新生血管性青光眼(NVG)的关系。方法:选取2021年1月~2022年1月成都市第六人民医院收治的145例接受玻璃体切割术PDR患者,根据术后1年是否发生NVG分为NVG组和非NVG组。酶联免疫吸附法检测房水Sema3A、Klotho、SDF-1水平。采用多因素Logistic回归分析影响PDR患者术后NVG的因素,受试者工作特征(ROC)曲线分析房水Sema3A、Klotho、SDF-1对PDR患者术后NVG的预测价值。结果:PDR患者随访1年,术后NVG发生率为17.24%。与非NVG组比较,NVG组房水Sema3A、SDF-1水平升高,Klotho水平降低(P<0.05)。多因素Logistic回归分析显示,术前虹膜新生血管和Sema3A、SDF-1升高为影响PDR患者术后NVG的独立危险因素,Klotho升高为独立保护因素(P<0.05)。ROC曲线分析显示,房水Sema3A、Klotho、SDF-1联合预测PDR患者术后NVG的曲线下面积(AUC)为0.913,大于房水Sema3A、Klotho、SDF-1单独预测的0.796、0.794、0.800。结论:房水Sema3A、SDF-1升高和Klotho降低与PDR患者术后NVG发生密切相关,房水Sema3A、Klotho、SDF-1联合检测对PDR患者术后NVG具有较高的预测价值。Objective:To investigate the relationship between aqueous humor semaphorin-3A(Sema3A),Klotho,stromal cell-derived factor-1(SDF-1)and postoperative neovascular glaucoma(NVG)in patients with proliferative diabetic retinopathy(PDR).Methods:145 patients admitted to Chengdu Sixth People's Hospital from January 2021 to January 2022 who underwent vitrectomy PDR were selected,and according to whether occurrence of NVG at 1 year after surgery,patients were divided into the NVG group and the non-NVG group.Enzyme-linked immunosorbent assay was used to detect the levels of aqueous humor Sema3A,Klotho and SDF-1.Multivariate Logistic regression analysis was used to analyze the factors affecting postoperative NVG in patients with PDR,and the predictive value of aqueous humor Sema3A,Klotho and SDF-1 on postoperative NVG in patients with PDR was analyzed by receiver operating characteristic(ROC)curve.Results:PDR patients were followed up for 1 year,and the incidence rate of postoperative NVG was 17.24%.Compared with the non-NVG group,the levels of aqueous humor Sema3A and SDF-1 in the NVG group were increased,and the level of Klotho was decreased(P<0.05).Multivariate Logistic regression analysis showed that preoperative iris neovascularization and elevated Sema3A and SDF-1 were independent risk factors affecting postoperative NVG in patients with PDR,and elevated Klotho was an independent protective factor(P<0.05).ROC curve analysis showed that the area under curve(AUC)of aqueous humor Sema3A,Klotho and SDF-1 predicted postoperative NVG in patients with PDR was 0.913,which was greater than the 0.796,0.794,and 0.800 predicted by aqueous humor Sema3A,Klotho and SDF-1 individually.Conclusion:Elevated aqueous humor Sema3A,SDF-1 and reduced Klotho are closely related to the occurrence of postoperative NVG in patients with PDR,and the combined detection of aqueous humor Sema3A,Klotho and SDF-1 has a high predictive value for postoperative NVG in patients with PDR.

关 键 词：增生型糖尿病视网膜病变 SEMA3A KLOTHO SDF-1 新生血管性青光眼 

分 类 号：R774.1[医药卫生—眼科]