糖基化终末产物受体基因多态性及糖化血红蛋白变异与脑白质疏松的关系  

The relationship between gene polymorphism of receptor for advanced glycation endproducts and glycation hemoglobin variation and brain white matter loosening

作　　者：潘才钰 盛和静 PAN Caiyu;SHENG Hejing(Department of Neurology,Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine,Wenzhou 325000,China;Department of Electrobiology,Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine,Wenzhou 325000,China)

机构地区：[1]温州市中西医结合医院神经内科,浙江温州325000 [2]温州市中西医结合医院电生理科,浙江温州325000

出　　处：《健康研究》2022年第4期427-431,441,共6页Health Research

基　　金：温州市科技计划项目(Y2020433)。

摘　　要：目的分析糖基化终末产物受体(receptor for advanced glycation endproducts,RAGE)基因多态性及糖化血红蛋白(HbA_(1 c))变异与脑白质疏松的关系。方法检测92例发生脑白质疏松的脑梗死合并2型糖尿病患者的RAGE基因多态性、HbA_(1 c)、空腹血糖(FPG),计算糖化血红蛋白变异指数(hemoglobin glycation index,HGI)。依据Fazekas评分法评估脑白质疏松程度,将患者分为中重度和轻度两组,Logistic回归分析RAGE基因多态性、HGI与脑白质疏松的关系。结果92例患者中,轻度脑白质疏松的有39例;中重度脑白质疏松的有53例;中重度组的rs2070600突变基因(S)频率、基因型GS占比及rs1800624突变基因(A)频率、基因型TA占比均高于轻度组,中重度组患者HGI高于轻度组,差异均有统计学意义(P<0.05);其余基因位点基因型比较,差异无统计学意义(P>0.05)。Logistic回归分析结果显示,RAGE基因位点rs2070600、rs1800624基因的多态性与脑白质疏松程度有关,HGI与脑白质疏松程度有关(OR>1,P<0.05)。结论RAGE基因位点rs2070600、rs1800624基因多态性及HbA_(1 c)变异均与脑白质疏松相关,RAGE基因多态性、HbA_(1 c)变异可能推进脑白质疏松进展。Objective To analyze the relationship between the gene polymorphism of receptors for advanced glycation endproducts(RAGE)and the variation of glycosylated hemoglobin(HbA_(1 c))and leukoaraiosis.Methods The RAGE gene polymorphism,HbA_(1 c),and fasting blood glucose(FPG)were detected in 92 patients with cerebral infarction complicated with type 2 diabetes who developed leukoaraiosis,and the hemoglobin glycation index(HGI)was calculated.The degree of leukoaraiosis was evaluated by the Fazekas scoring method,and the patients were divided into moderate and severe groups and mild groups.The relationship between RAGE gene polymorphism,HGI,and leukoaraiosis was analyzed by Logistic regression.Results Of the 92 patients,39 had mild leukosis,and 53 had moderate to severe leukosis.The frequency of rs2070600 mutation gene(S),genotype GS proportion,the frequency of rs1800624 mutation gene(A),and the proportion of genotype TA in the moderate and severe group were all higher than those in the mild group.Patients in the moderate to the severe group had higher HGI than those in the mild group.The differences were all statistically significant(P<0.05).There was no significant difference in genotypes of other loci(P>0.05).Logistic regression analysis showed that the polymorphisms of RAGE gene loci rs2070600 and rs1800624 were related to the degree of leukoaraiosis,and HGI was related to the degree of leukoaraiosis(OR>1,P<0.05).Conclusions The polymorphisms of RAGE gene loci rs2070600,rs1800624 and HbA 1c mutation are related to leukoaraiosis.The polymorphisms of the RAGE gene and HbA 1c mutation may promote the progress of leukoaraiosis.

关 键 词：脑白质疏松 2型糖尿病 糖基化终末产物受体 糖化血红蛋白 

分 类 号：R742[医药卫生—神经病学与精神病学]