结肠黑变病研究进展  

Research progress of melanosis coli

作　　者：杨玄 付雯[1] 崔月萌 王莹[1] 徐声润 常江[1] YANG Xuan;FU Wen;CUI Yue-meng;WANG Ying;XU Sheng-run;CHANG Jiang(Department of Gastroenterology,the Second Affiliated Hospital of Kunming Medical University,Kunming,Yunnan 650101,China)

机构地区：[1]昆明医科大学第二附属医院消化内科,云南昆明650101

出　　处：《中国临床研究》2022年第8期1147-1150,共4页Chinese Journal of Clinical Research

基　　金：云南省教育厅科学研究基金项目(2021J0251);昆明医科大学研究生创新基金(2021S214)。

摘　　要：结肠黑变病(MC)是一种结肠黏膜色素沉着性肠病,在老年群体中更常见,患者多有长期便秘及服用蒽醌类泻剂史,一般认为蒽醌类药剂服用史为其发病的关键因素,然而具体的病因及发病机制至今仍不甚明确。大量研究发现MC更易伴发结肠腺瘤性息肉,在结肠癌患者中检出MC的概率亦高于一般人群,实验研究也证实MC与结肠癌在某些差异表达基因和蛋白方面有一定关联,故推断MC可能与结肠息肉和结肠癌之间具有内在联系性。加深对MC的认识可能对结肠肿瘤的预防也有一定意义,本文对MC研究进展及其与结肠肿瘤的关系作一综述。Melanosis coli(MC)is a pigmented bowel disease of colonic mucosa and more common in the elderly.Most patients have a long-term history of constipation and taking anthraquinone laxatives.It is generally considered that the history of taking anthraquinone laxatives is the key factor in the pathogenesis of MC.However,its etiology and pathogenesis are still unclear.Many studies have found that MC is more likely to be associated with colonic adenomatous polyps,and the probability of detecting MC in colon cancer patients is also higher than that in the general population.Experimental studies have also confirmed that MC is associated with some differentially expressed genes and proteins in colon cancer.So,deepening understanding of MC may also have clinical significance for the prevention of colon tumors.This paper reviews the research progress of MC and its relationship with colon tumors.

关 键 词：结肠黑变病 结肠息肉 结肠癌 蒽醌类泻剂 

分 类 号：R574.6[医药卫生—消化系统]