胃癌患者幽门螺杆菌感染与EGF、EGFR、HER2表达相关性分析  被引量:6

Correlation between Helicobacter pylori infection and expression of EGF,EGFR and HER2 in patients with gastric cancer

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作  者:王楠[1,2] 房玉海 高雪茹 姜葵 WANG Nan;FANG Yuhai;GAO Xueru;JIANG Kui(Department of Gastroenterology,General Hospital of Tianjin Medical University,Tianjin 300042,China;Department of Gastroenterology,Tianjin Dongli Hospital,Tianjin 300300,China)

机构地区:[1]天津医科大学总医院消化内科,300042 [2]天津市东丽医院消化内科,300300

出  处:《重庆医学》2022年第16期2781-2784,2788,共5页Chongqing medicine

基  金:天津市科技计划项目(19ZXDBSY00020)。

摘  要:目的探讨胃癌患者幽门螺杆菌(Hp)感染与表皮生长因子(EGF)、EGF受体(EGFR)、人EGF受体-2(HER2)表达的关系。方法回顾性分析2019年9月至2021年9月在天津医科大学总医院和天津市东丽医院经病理检查确诊的249例胃癌患者的临床资料。比较Hp阳性与阴性患者临床资料的差异,使用Spearman相关性分析评估Hp感染程度与肿瘤和淋巴结中EGF、EGFR、HER2蛋白表达的相关性。结果249例患者中Hp阳性104例(41.77%),Hp阴性145例(58.23%)。Hp阳性和阴性患者一般资料比较差异均无统计学意义(P>0.05)。Hp感染程度与胃癌患者EGF、EGFR、HER2表达无关,差异均无统计学意义(P>0.05)。肿瘤组织中HER2表达与EGF(r=-0.683)、EGFR(r=0.461)、淋巴结中HER2表达(r=0.734)中度相关。而EGF在肿瘤和淋巴结中的表达均与EGFR表达相关。结论胃癌患者Hp感染与胃癌组织中EGF、EGFR、HER2表达无关。Objective To investigate the relationship between Helicobacter pylori(Hp)infection and the expression of epidermal growth factor(EGF),EGF receptor(EGFR)and human epidermal growth factor receptor-2(HER2)in the patients with gastric cancer.Methods The clinical data of 249 patients with gastric cancer pathologically diagnosed in the General Hospital of Tianjin Medical University and Tianjin Dongli Hospital from September 2019 to September 2021 were analyzed retrospectively.The differences in the clinical data were compared between the patients with Hp positive and negative.The Spearman correlation analysis was used to evaluate the correlation between the degree of Hp infection and the expression of EGF,EGFR and HER2 proteins in tumors and lymph nodes.Results Among 249 cases,104 cases(41.77%)were Hp positive and 145 cases(58.24%)were Hp negative.There was no statistically significant difference in the general data between the patients with Hp positive and negative(P>0.05).There was no correlation between the degree of Hp infection and the expression of EGF,EGFR and HER2 in the patients with gastric cancer,and the difference was not statistically significant(P>0.05).The HER2 expression in tumor tissue was moderately correlated with EGF(r=-0.683),EGFR(r=0.461)and HER2 expression in local lymph nodes(r=0.734).The expression of EGF in tumors and lymph nodes was correlated with the level of EGFR.Conclusion There is no correlation between Hp infection and the expression of EGF,EGFR and HER2 in gastric cancer tissue of the patients with gastric cancer.

关 键 词:胃癌 幽门螺杆菌 人表皮生长因子 相关性分析 

分 类 号:R735.2[医药卫生—肿瘤]

 

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